Results 11 to 20 of about 17,741,837 (346)

Antiviral activity of berberine [PDF]

Archives of Virology, 2020
Plants are a rich source of new antiviral, pharmacologically active agents. The naturally occurring plant alkaloid berberine (BBR) is one of the phytochemicals with a broad range of biological activity, including anticancer, anti-inflammatory and ...
A. Warowicka, R. Nawrot, A. Gozdzicka-Jozefiak   +2 more
semanticscholar   +3 more sources

Broad-spectrum antiviral activity of ebselen [PDF]

Scientific Reports
Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Kunlakanya Jitobaom, Usa Boonyuen, Chompunuch Boonarkart, Thanyaporn Sirihongthong, Prasert Auewarakul   +4 more
doaj   +2 more sources

Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro [PDF]

Antiviral Research, 2017
Background: By modulating the antiviral immune response via vitamin D receptor, the active form of vitamin D (1,25‐dihydroxyvitamin D, calcitriol) could play a central role in protection against respiratory virus infections.
A. Telcian, M. Zdrenghea, M. Edwards, V. Laza-Stanca, P. Mallia, S. Johnston, L. Stanciu   +6 more
semanticscholar   +2 more sources

ANTIVIRAL TEXTILES AND ANTIVIRAL ACTIVITY TESTING - THE USE OF BACTERIOPHAGE SURROGATE FOR ANTIVIRAL ACTIVITY TESTING [PDF]

Fibres and Textiles
The risk of dissemination of highly contagious viral diseases (as COVID-19, Ebola) led in the increasing need to develop functional textiles and surfaces with antiviral effect. Antiviral textiles are designed to reduce the viability and infectivity of viruses on their surfaces and by this way to reduce the cases of infection (including re-infection or ...
Ludmila Tvrzová, Anna Bláhová, Jakub Fojt, Hana Doubková, Jiří Procházka   +4 more
openaire   +2 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity [PDF]

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +2 more sources

Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3

International Journal of Nanomedicine, 2013
Swapnil Gaikwad,1 Avinash Ingle,1 Aniket Gade,1 Mahendra Rai,1 Annarita Falanga,3 Novella Incoronato,2 Luigi Russo,2 Stefania Galdiero,3 Massimilano Galdiero2 1Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, Maharashtra, India;
Gaikwad S, Ingle A, Gade A, Rai M, Falanga A, Incoronato N, Russo L, Galdiero S, Galdiero M   +8 more
doaj   +2 more sources

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model

Science, 2021
Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
Jing-Xin Qiao, Yue-Shan Li, R. Zeng, Feng-Liang Liu, Rong-Hua Luo, Chong Huang, Yi-Fei Wang, Jie Zhang, Bao-Xue Quan, Chenjian Shen, X. Mao, Xin-Lei Liu, Wei-Ning Sun, Wei Yang, X. Ni, Kai Wang, Ling Xu, Zilei Duan, Qingcui Zou, Hai-Lin Zhang, Wang Qu, Yang-Hao-Peng Long, Ming-Hua Li, Rui Yang, Xiao-Long Liu, Jing You, Yang-Li Zhou, R. Yao, Wen-Pei Li, Jing-Ming Liu, Pei Chen, Yang Liu, Gui-Feng Lin, Xin Yang, Jun Zou, Lin-Li Li, Yiguo Hu, Guangwen Lu, Wei-Min Li, Yu-Quan Wei, Yong-tang Zheng, Jian-Kun Lei, Shengyong Yang   +42 more
semanticscholar   +1 more source

Molnupiravir and Its Antiviral Activity Against COVID-19

Frontiers in Immunology, 2022
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat and economic burden.
L. Tian, Zehan Pang, Mao-Chen Li, Fuxing Lou, X. An, Shaozhou Zhu, Li-Hua Song, Y. Tong, Hua-Hao Fan, Jun-Fen Fan   +9 more
semanticscholar   +1 more source

Antiviral activity of bacterial TIR domains via immune signalling molecules

Nature, 2021
The Toll/interleukin-1 receptor (TIR) domain is a canonical component of animal and plant immune systems1,2. In plants, intracellular pathogen sensing by immune receptors triggers their TIR domains to generate a molecule that is a variant of cyclic ADP ...
G. Ofir, Ehud Herbst, Maya Baroz, Daniel Cohen, A. Millman, Shany Doron, Nitzan Tal, Daniel B. A. Malheiro, S. Malitsky, Gil Amitai, R. Sorek   +10 more
semanticscholar   +1 more source

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

EBioMedicine, 2021
Background Antivirals are needed to combat the COVID-19 pandemic, which is caused by SARS-CoV-2. The clinically-proven protease inhibitor Camostat mesylate inhibits SARS-CoV-2 infection by blocking the virus-activating host cell protease TMPRSS2. However,
M. Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, Prerna Arora, L. K. Sørensen, O. Søgaard, J. Hasselstrøm, M. Winkler, Tim Hempel, L. Raich, S. Olsson, O. Danov, D. Jonigk, Takashi Yamazoe, Katsura Yamatsuta, H. Mizuno, S. Ludwig, Frank Noé, M. Kjolby, Armin Braun, J. Sheltzer, S. Pöhlmann   +22 more
semanticscholar   +1 more source