Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death [PDF]
Antioxidants, 2021 Reactive oxygen species (ROS) and intracellular iron levels are critical modulators of lipid peroxidation that trigger iron-dependent non-apoptotic ferroptosis in myocardial ischemia-reperfusion (I/R) injury.
Bong-Woo Park +2 more
exaly +9 more sources
Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells [PDF]
Marine Drugs, 2019 Cardiac progenitor cells (CPCs) are resident stem cells present in a small portion of ischemic hearts and function in repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing cell viability.
Jong Seong Ha +2 more
exaly +9 more sources
Multifaceted Clinical Effects of Echinochrome [PDF]
Marine Drugs, 2021 The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins.
Elena Vasileva +2 more
exaly +6 more sources
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice [PDF]
Marine Drugs, 2023 Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome®. EchA has antioxidant, anti-inflammatory, and antimicrobial effects. However, its effects on diabetic nephropathy (DN)
Trong Kha Pham +11 more
doaj +4 more sources
Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration [PDF]
Marine Drugs, 2023 Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of the clinically approved drug Histochrome®.
Stefanos Kikionis +8 more
doaj +6 more sources
SUPRESSION OF MICROSOMAL OXIDATION WEAKENS HISTOCHROME’S DIURETIC EFFECT AT RATS [PDF]
Бюллетень сибирской медицины, 2013 Histochrome is the medicinal form of echinochrome (2, 3, 5, 6, 8-pentahydroxy-7-ethyl-1,4-naphthoquinone). Arisen during clinical application of the drug questions concerning its biotransformation have predetermined the aim of this research: to study ...
O. S. Talalaeva +5 more
doaj +6 more sources
Morphological evidence of anabolic action of the drug histochrome in rats [PDF]
Бюллетень сибирской медицины, 2018 The aim of the investigation was to assess histochrome’s anabolic effect as a consequence of treatment of various doses in rats in conditions of prolonged physical training.Materials and methods.
O. S. Talalaeva +3 more
doaj +6 more sources
Experimental histochrome's effect on the renal excretory function [PDF]
Бюллетень сибирской медицины, 2011 The aim of present investigation was to establish possible histochrome's effect on the renal excretory function. During 10 days was being administrated histochrome by subcutaneous injections in dose 10 mg/kg.
O. S. Talalayeva +6 more
doaj +6 more sources
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products [PDF]
Molecules, 2020 Echinochrome A (Ech A, 1) is one of the main pigments of several sea urchin species and is registered in the Russian pharmacopeia as an active drug substance (Histochrome®), used in the fields of cardiology and ophthalmology.
Natalia P. Mishchenko +5 more
doaj +4 more sources
A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells [PDF]
Marine Drugs, 2018 Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim +11 more
doaj +4 more sources