Results 1 to 10 of about 7,497 (214)

The Trypanocidal Activity of Naphthoquinones: A Review [PDF]

Molecules, 2009
Naphthoquinones are compounds present in several families of higher plants. Their molecular structures confer redox properties, and they are involved in multiple biological oxidative processes.
Solange L de Castro, Antonio Ventura Pinto   +1 more
exaly   +7 more sources

The Relevance and Insights on 1,4-Naphthoquinones as Antimicrobial and Antitumoral Molecules: A Systematic Review

Pharmaceuticals, 2023
Natural product derivatives are essential in searching for compounds with important chemical, biological, and medical applications. Naphthoquinones are secondary metabolites found in plants and are used in traditional medicine to treat diverse human ...
Denisse de Loera, Lluvia I López, Sarai Vega Rodríguez   +2 more
exaly   +3 more sources

In Vitro Evaluation of Natural Sesquiterpene Lactones and Naphthoquinones Against Pancreatic Ductal Adenocarcinoma Cells [PDF]

Molecules
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, highlighting the need to identify novel bioactive compounds with antitumor potential. Natural products constitute a valuable source of molecules with anticancer activity.
Nadia T. Mirakian, Rubén F. Iácono, Viviana B. Pulido, Matías A. Pibuel, Silvina L. Lompardía, Laura C. Laurella, Nicolás Pérez-Mauad, Cesar A. N. Catalán, Tomás Lombardo, Martín M. Ledesma, Adriana Carlucci, Valeria P. Sülsen, Daniela L. Papademetrio   +12 more
doaj   +2 more sources

Naphthoquinones as a Promising Class of Compounds for Facing the Challenge of Parkinson’s Disease

Pharmaceuticals, 2023
Parkinson’s disease (PD) is a degenerative disease that affects approximately 6.1 million people and is primarily caused by the loss of dopaminergic neurons.
Thaís Barreto Santos, Leonardo Gomes Cavalieri de Moraes, Paulo Anastácio Furtado Pacheco, Douglas Galdino dos Santos, Rafaella Machado de Assis Cabral Ribeiro, Caroline dos Santos Moreira, David Rodrigues da Rocha   +6 more
doaj   +1 more source

Synthesis of 4-Aryl-1,2-naphthoquinones via a conjugate addition-oxidation reaction catalyzed by p-toluenesulfonic acid

Results in Chemistry, 2022
A catalytic conjugate addition-oxidation reaction of 1,2-naphthoquinones has been investigated. p-Toluenesulfnoic acid was found to be the most effective catalyst for the reaction.
Watcharapon Prasitwatcharakorn, Chaiwat Rujirasereesakul, Torsak Luanphaisarnnont   +2 more
doaj   +1 more source

1,2-Naphthoquinone-4-sulfonic acid salts in organic synthesis

Beilstein Journal of Organic Chemistry, 2022
Several low molecular weight naphthoquinones are very useful in organic synthesis. These compounds have given rise to thousands of other naphthoquinones that have been tested against various microorganisms and pharmacological targets, including being ...
Ruan Carlos B. Ribeiro, Patricia G. Ferreira, Amanda de A. Borges, Luana da S. M. Forezi, Fernando de Carvalho da Silva, Vitor F. Ferreira   +5 more
doaj   +1 more source

Cytotoxicity, hemolysis and in vivo acute toxicity of 2-hydroxy-3-anilino-1,4-naphthoquinone derivatives

Toxicology Reports, 2016
The 1,4-naphthoquinones, important members of the family of quinones are used as both crude extracts and as compound manipulated by the pharmaceutical industry.
Valeska Santana de Sena Pereira, Cláudio Bruno Silva de Oliveira, Fernando Fumagalli, Flávio da Silva Emery, Naisandra Bezerra da Silva, Valter F. de Andrade-Neto   +5 more
doaj   +1 more source

In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches

Pharmaceuticals, 2022
Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host.
Lina S. Prieto Cárdenas, Karen A. Arias Soler, Diana L. Nossa González, Wilson E. Rozo Núñez, Agobardo Cárdenas-Chaparro, Pablo R. Duchowicz, Jovanny A. Gómez Castaño   +6 more
doaj   +1 more source

1,4-Naphthoquinones: From Oxidative Damage to Cellular and Inter-Cellular Signaling

Molecules, 2014
Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox signaling. Here, contributions of redox cycling and alkylating properties of quinones (both natural and synthetic, such as plumbagin, juglone, lawsone, menadione ...
Lars-Oliver Klotz, Xiaoqing Hou, Claus Jacob   +2 more
doaj   +1 more source

Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors

Molecules, 2023
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including agonists and antagonists of ...
Paulo Anastácio Furtado Pacheco, Daniel Tadeu Gomes Gonzaga, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, David Rodrigues da Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Robson Xavier Faria   +7 more
doaj   +1 more source