Results 11 to 20 of about 4,751 (182)

In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches

Pharmaceuticals, 2022
Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host.
Lina S. Prieto Cárdenas, Karen A. Arias Soler, Diana L. Nossa González, Wilson E. Rozo Núñez, Agobardo Cárdenas-Chaparro, Pablo R. Duchowicz, Jovanny A. Gómez Castaño   +6 more
doaj   +1 more source

Biomimetic Synthesis of Antimalarial Naphthoquinones [PDF]

Journal of the American Chemical Society, 2005
The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described. Pinnatal, isopinnatal, sterekunthals A and B, pyranokunthones A and B, and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps.
Jeremiah P, Malerich, Thomas J, Maimone, Gregory I, Elliott, Dirk, Trauner   +3 more
openaire   +3 more sources

Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones.

PLoS ONE, 2014
Allergic disorders are characterized by an abnormal immune response towards non-infectious substances, being associated with life quality reduction and potential life-threatening reactions.
Brígida R Pinho, Carla Sousa, Patrícia Valentão, Jorge M A Oliveira, Paula B Andrade   +4 more
doaj   +1 more source

Synthesis, Biological Evaluation and Molecular Modeling Studies of Naphthoquinone Sulfonamides and Sulfonate Ester Derivatives as P2X7 Inhibitors

Molecules, 2023
ATP acts in the extracellular environment as an important signal, activating a family of receptors called purinergic receptors. In recent years, interest in the potential therapeutics of purinergic components, including agonists and antagonists of ...
Paulo Anastácio Furtado Pacheco, Daniel Tadeu Gomes Gonzaga, Natalia Lidmar von Ranke, Carlos Rangel Rodrigues, David Rodrigues da Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Robson Xavier Faria   +7 more
doaj   +1 more source

MTMS-Based Aerogel Constructs for Immobilization of Plant Hairy Roots: Effects on Proliferation of Rindera graeca Biomass and Extracellular Secretion of Naphthoquinones

Journal of Functional Biomaterials, 2021
Unique biosynthetic abilities revealed by plants determine in vitro cultures of hairy roots as a suitable source of pharmaceutically relevant bioactive compounds.
Bartosz Nowak, Mateusz Kawka, Kamil Wierzchowski, Katarzyna Sykłowska-Baranek, Maciej Pilarek   +4 more
doaj   +1 more source

Different extracts and isolated substances from the root of Onosma visianii Clem. as antifungal agents [PDF]

Kragujevac Journal of Science, 2023
The aim of this study was to determine the antifungal activity of extracts and isolated substances from the root of Onosma visianii Clem. (Boraginaceae) by determining the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC).
Radojević Ivana D., Marković Katarina G., Grujović Mirjana Ž., Vukić Milena D., Vuković Nenad L.   +4 more
doaj  

Plumbagin, a Potent Naphthoquinone from Nepenthes Plants with Growth Inhibiting and Larvicidal Activities

Molecules, 2021
Some plant species are less susceptible to herbivore infestation than others. The reason for this is often unknown in detail but is very likely due to an efficient composition of secondary plant metabolites.
Asifur Rahman-Soad, Alberto Dávila-Lara, Christian Paetz, Axel Mithöfer   +3 more
doaj   +1 more source

Activity of Some Plant and Fungal Metabolites towards Aedes albopictus (Diptera, Culicidae)

Toxins, 2021
Aedes albopictus (Skuse) is a widespread mosquito, a vector of important human arboviruses, including Chikungunya, Dengue and Zika. It is an extremely difficult species to control even for the onset of resistances to chemicals insecticides, therefore ...
Sonia Ganassi, Marco Masi, Pasqualina Grazioso, Antonio Evidente, Antonio De Cristofaro   +4 more
doaj   +1 more source

Water, Alcohols, Amines, and Amides as Formal Hydrogen‐Atom‐Transfer Reagents Through Activation With Redox‐Active Lewis Acids

Angewandte Chemie, EarlyView.
Protic molecules containing strong O─H or N─H bonds typically resist hydrogen‐atom abstraction because of the high reactivity of the resulting heteroatom‐centered radicals. However, association of the protic molecules with redox‐active Lewis acids can provide powerful hydrogen‐atom donors or proton‐coupled‐electron‐transfer reagents.
Petra Vojáčková, Armido Studer
wiley   +2 more sources

Naphthoquinone Derivatives as Scaffold to Develop New Drugs for Tuberculosis Treatment

Frontiers in Microbiology, 2018
Despite being a curable disease, tuberculosis (TB) remains a public health problem worldwide mainly due to lengthy treatment, as well as its toxic effects, TB/HIV co-infection and the emergence of resistant Mycobacterium tuberculosis strains.
Priscila C. B. Halicki, Laís A. Ferreira, Kelly C. G. De Moura, Paula F. Carneiro, Karina P. Del Rio, Tatiane dos S. C. Carvalho, Maria do C. F. R. Pinto, Pedro E. A. da Silva, Daniela F. Ramos   +8 more
doaj   +1 more source