A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells [PDF]
Marine Drugs, 2018 Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim +11 more
doaj +5 more sources
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products [PDF]
Molecules, 2020 Echinochrome A (Ech A, 1) is one of the main pigments of several sea urchin species and is registered in the Russian pharmacopeia as an active drug substance (Histochrome®), used in the fields of cardiology and ophthalmology.
Natalia P. Mishchenko +5 more
doaj +3 more sources
Acetylcholinesterase Inhibitory Activity of Pigment Echinochrome A from Sea Urchin Scaphechinus mirabilis [PDF]
Marine Drugs, 2014 Echinochrome A (EchA) is a dark-red pigment of the polyhydroxynaphthoquinone class isolated from sea urchin Scaphechinus mirabilis. Acetylcholinesterase (AChE) inhibitors are used in the treatment of various neuromuscular disorders, and are considered as
Sung Ryul Lee +9 more
doaj +4 more sources
Multifaceted Clinical Effects of Echinochrome
Marine Drugs, 2021 The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins.
Hyoung Kyu Kim +4 more
doaj +3 more sources
ANTIVIRAL AND ANTIOXIDANT ACTIVITY OF THE COMPOSITION OF COMPOUNDS BASED ON ECHINOCHROME A
Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 The aim of this study was to examine in vitro the antioxidant and antiviral activity of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1).
N. V. Krylova +8 more
doaj +3 more sources
The Protective Effect of Echinochrome A on Extracellular Matrix of Vocal Folds in Ovariectomized Rats [PDF]
Marine Drugs, 2020 Here, we investigated the effects of sex hormones on extracellular matrix (ECM)-related gene expression in the vocal fold lamina propria of ovariectomized (after ovary removal) rats and verified whether echinochrome A (ECH) exerts any therapeutic effects
Ji Min Kim +12 more
doaj +3 more sources
Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs [PDF]
Marine Drugs, 2014 Echinochrome A (Ech A) is a naphthoquinoid pigment from sea urchins that possesses antioxidant, antimicrobial, anti-inflammatory and chelating abilities.
Seung Hun Jeong +10 more
doaj +4 more sources
Marine Drugs, 2019 Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies.
Ran Kim +7 more
doaj +3 more sources
Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells [PDF]
Marine Drugs, 2019 Echinochrome A (Ech A), a natural pigment extracted from sea urchins, is the active ingredient of a marine-derived pharmaceutical called ‘histochrome’.
Su-Jeong Oh +10 more
doaj +3 more sources
Marine Natural Products Rescuing the Eye: A Narrative Review. [PDF]
Mar DrugsDifferent degrees of visual impairment lead to a decrease in patient wellbeing, which has an adverse effect on many facets of social and professional life. Eye disorders can affect several parts of the eye, most notably the retina and the cornea, and the
Lixi F, Vitiello L, Giannaccare G.
europepmc +3 more sources