Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling [PDF]
Marine Drugs, 2022 Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer.
Elena Vasileva +2 more
exaly +4 more sources
Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction [PDF]
Marine Drugs, 2022 Endothelial–mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) transition into mesenchymal cells (e.g., myofibroblasts and smooth muscle cells) and induce fibrosis of cells/tissues, due to ischemic conditions in the heart ...
Woochul Chang +2 more
exaly +4 more sources
Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway [PDF]
Marine Drugs, 2023 Asthma is a persistent inflammatory disease of the bronchi characterized by oxidative stress, airway remodeling, and inflammation. Echinochrome (Ech) is a dark-red pigment with antioxidant and anti-inflammatory activities.
Islam Ahmed Abdelmawgood +7 more
doaj +2 more sources
Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats [PDF]
PeerJ, 2023 Background Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes’ average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins.
Mona S. E. F. El-Shehry +11 more
doaj +3 more sources
Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice [PDF]
Marine Drugs, 2023 Abnormal sulfide catabolism, especially the accumulation of hydrogen sulfide (H2S) during hypoxic or inflammatory stresses, is a major cause of redox imbalance-associated cardiac dysfunction.
Xiaokang Tang +15 more
doaj +2 more sources
Multifaceted Clinical Effects of Echinochrome
Marine Drugs, 2021 The marine drug histochrome is a special natural antioxidant. The active substance of the drug is echinochrome A (Ech A, 7-ethyl-2,3,5,6,8-pentahydroxy-1,4-naphthoquinone), the most abundant quinonoid pigment in sea urchins.
Elena Vasileva +2 more
exaly +3 more sources
Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro [PDF]
Marine DrugsLiposomal drug delivery systems are successfully used in various fields of medicine for external and systemic applications. Marine organisms contain biologically active substances that have a unique structure and exhibit a wide range of biological ...
Ekaterina S. Menchinskaya +7 more
doaj +2 more sources
Multi-omic analysis reveals genes and proteins integral to bioactivity of Echinochrome A isolated from the waste stream of the sea urchin industry in Aotearoa New Zealand. [PDF]
Food Sci NutrThe mechanism of action of Echinochrome A (Ech A) was evaluated using unbiased genomic and proteomic analyses. Growth analyses of gene deletions and measurements of protein abundance identified the importance of 20 genes and 92 proteins. The antioxidant activity of Ech A may begin with alterations in DNA replication, followed by iron chelation and ...
Hammond J +7 more
europepmc +2 more sources
Antiviral and Antioxidant Properties of Echinochrome A
Marine Drugs, 2018 The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1).
Galina Leonova +2 more
exaly +3 more sources
Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats [PDF]
Marine Drugs, 2022 Post-menopausal dry mouth or xerostomia is caused by reduced salivary secretion. This study aimed to investigate the efficacy of echinochrome A (Ech A) in alleviating submandibular gland dysfunctions in ovariectomized rats that mimic menopause.
Ji-Min Kim +12 more
doaj +2 more sources