PHNQ from Evechinus chloroticus Sea Urchin Supplemented with Calcium Promotes Mineralization in Saos-2 Human Bone Cell Line. [PDF]
Mar Drugs, 2020 Polyhydroxylated naphthoquinones (PHNQs), known as spinochromes that can be extracted from sea urchins, are bioactive compounds reported to have medicinal properties and antioxidant activity.
Hou Y +9 more
europepmc +2 more sources
COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN [PDF]
Медицинская иммунология, 2018 This work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome
A. V. Tsybulsky +5 more
doaj +2 more sources
Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats [PDF]
Natural Products and Bioprospecting, 2019 Obesity has been identified with an expanded danger of a progression of illnesses that include different organ-frameworks of the body. In the present examination, we evaluated the hypolipidemic properties of Echinochrome (Ech) pigment in a high-fat diet (
Sohair R. Fahmy +4 more
doaj +3 more sources
Marine Drugs, 2020 Here, we investigated the effects of sex hormones on extracellular matrix (ECM)-related gene expression in the vocal fold lamina propria of ovariectomized (after ovary removal) rats and verified whether echinochrome A (ECH) exerts any therapeutic effects
Ji Min Kim +12 more
doaj +2 more sources
Marine Drugs, 2018 Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Hyoung Kyu Kim +11 more
doaj +2 more sources
Brazilian Journal of Biology, 2019 The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight).
Sohair R Fahmy +4 more
doaj +2 more sources
Ecotoxicology and Environmental SafetyEchinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored.
Su-Jin Lee +11 more
doaj +2 more sources
Multi-omic analysis reveals genes and proteins integral to bioactivity of Echinochrome A isolated from the waste stream of the sea urchin industry in Aotearoa New Zealand. [PDF]
Food Sci NutrThe mechanism of action of Echinochrome A (Ech A) was evaluated using unbiased genomic and proteomic analyses. Growth analyses of gene deletions and measurements of protein abundance identified the importance of 20 genes and 92 proteins. The antioxidant activity of Ech A may begin with alterations in DNA replication, followed by iron chelation and ...
Hammond J +7 more
europepmc +2 more sources
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice. [PDF]
Mar Drugs, 2023 Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome®. EchA has antioxidant, anti-inflammatory, and antimicrobial effects. However, its effects on diabetic nephropathy (DN)
Pham TK +11 more
europepmc +2 more sources
Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration. [PDF]
Mar Drugs, 2023 Echinochrome A (EchA), a marine bioactive pigment isolated from various sea urchin species, is the active agent of the clinically approved drug Histochrome®.
Kikionis S +8 more
europepmc +4 more sources