A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells [PDF]
Marine Drugs, 2018 Echinochrome A (EchA) is a marine bioproduct extracted from sea urchins having antioxidant, antimicrobial, anti-inflammatory, and chelating effects, and is the active component of the clinical drug histochrome.
Min Kim +2 more
exaly +4 more sources
Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction [PDF]
Marine Drugs, 2022 Endothelial–mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) transition into mesenchymal cells (e.g., myofibroblasts and smooth muscle cells) and induce fibrosis of cells/tissues, due to ischemic conditions in the heart ...
Byeong-Wook Song +14 more
doaj +4 more sources
Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat [PDF]
Marine Drugs, 2019 Of late, researchers have taken interest in alternative medicines for the treatment of brain ischemic stroke, where full recovery is rarely seen despite advanced medical technologies.
Ran Kim, Hyoung Kyu Kim, Jin Han
exaly +4 more sources
Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression [PDF]
Marine Drugs, 2021 Sang Woo Ahn +2 more
exaly +4 more sources
Echinochrome A Improves Exercise Capacity during Short-Term Endurance Training in Rats [PDF]
Marine Drugs, 2015 Echinochrome A (Echi A) improves mitochondrial function in the heart; however, its effects on skeletal muscle are still unclear. We hypothesized that Echi A administration during short-term exercise may improve exercise capacity. Twenty-four male Sprague-
Natalya Mishchenko +2 more
exaly +6 more sources
Natural Substances vs. Approved Drugs in the Treatment of Main Cardiovascular Disorders-Is There a Breakthrough? [PDF]
Antioxidants (Basel), 2023 Cardiovascular diseases (CVDs) are a group of diseases with a very high rate of morbidity and mortality. The clinical presentation of CVDs can vary from asymptomatic to classic symptoms such as chest pain in patients with myocardial infarction.
Grujić-Milanović J +6 more
europepmc +4 more sources
ANTIVIRAL AND ANTIOXIDANT ACTIVITY OF THE COMPOSITION OF COMPOUNDS BASED ON ECHINOCHROME A
Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 The aim of this study was to examine in vitro the antioxidant and antiviral activity of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1).
N. V. Krylova +8 more
doaj +2 more sources
Медицинская иммунология, 2018 This work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome
A. V. Tsybulsky +5 more
doaj +3 more sources
Multi-target bioactivity of summer quinones production in the Persian Gulf burrowing black-type sea urchin [PDF]
Heliyon, 2022 After harvesting the sea urchin gonads for Japanese food “uni” echinoculture systems, the remaining shells and spines are considered waste. However, the material of shells and spines is thought to be rich in natural bioactive molecules. The current study
Soolmaz Soleimani +3 more
doaj +2 more sources
Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats [PDF]
Brazilian Journal of Biology, 2019 The present study was designed to evaluate the protective effects of echinochrome (Ech) on intrahepatic cholestasis in rats induced by a single (i.p.) injection of alpha-naphthylisothiocyanate (ANIT) (75 mg/kg body weight).
Sohair R Fahmy +4 more
doaj +3 more sources