Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium [PDF]
Marine Drugs, 2022 The diverse therapeutic feasibility of the sea urchin-derived naphthoquinone pigment, Echinochrome A (Ech A), has been studied. Simple and noninvasive administration routes should be explored, to obtain the feasibility. Although the therapeutic potential
Ji-Su Ahn +16 more
doaj +4 more sources
Effects of Carrageenans on Biological Properties of Echinochrome [PDF]
Marine Drugs, 2018 Sea urchin pigment echinochrome A (Ech), a water-insoluble compound, is the active substance in the cardioprotective and antioxidant drug Histochrome® (PIBOC FEB RAS, Moscow, Russia).
Natalia Mishchenko, , Anna Kravchenko
exaly +5 more sources
Liposomal Form of the Echinochrome-Carrageenan Complex [PDF]
Marine Drugs, 2018 Inclusion of drugs in liposomes offers the potential for localized and sustained delivery to mucosal surfaces. The inclusion of the carrageenan matrix with echinochrome A ((Ech)—the active substance of the drug Histochrome) in liposomes was studied.
Natalia Mishchenko +2 more
exaly +5 more sources
Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma [PDF]
Marine Drugs, 2021 Scleroderma is an autoimmune disease caused by the abnormal regulation of extracellular matrix synthesis and is activated by non-regulated inflammatory cells and cytokines.
Ki-Tae Ha +2 more
exaly +5 more sources
Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products [PDF]
Molecules, 2020 Echinochrome A (Ech A, 1) is one of the main pigments of several sea urchin species and is registered in the Russian pharmacopeia as an active drug substance (Histochrome®), used in the fields of cardiology and ophthalmology.
Elena Vasileva +2 more
exaly +5 more sources
Antiherpetic Activity of Carrageenan Complex with Echinochrome A and Its Liposomal Form [PDF]
International Journal of Molecular Sciences, 2022 Herpes simplex virus (HSV) infections, the incidence of which is still widespread throughout the world, are actualizing the search and development of new, more effective antiherpetic drugs. The development of multifunctional drug delivery systems, including liposome-based ones, has become a relevant and attractive concept in nanotechnology. The ability
Olga Iunikhina +2 more
exaly +4 more sources
Multi-target bioactivity of summer quinones production in the Persian Gulf burrowing black-type sea urchin [PDF]
Heliyon, 2022 After harvesting the sea urchin gonads for Japanese food “uni” echinoculture systems, the remaining shells and spines are considered waste. However, the material of shells and spines is thought to be rich in natural bioactive molecules. The current study
Soolmaz Soleimani +3 more
doaj +2 more sources
Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome [PDF]
Marine Drugs, 2021 Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA is a polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. EchA is the most studied molecule
Tamara Rubilar +3 more
doaj +2 more sources
Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia [PDF]
Marine Drugs, 2022 We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of angiotensin II (Ang II) through an osmotic pump (1 μg/kg/min) on GD 8 increased systolic and diastolic
Huixing Cui +6 more
doaj +2 more sources
PHNQ from Evechinus chloroticus Sea Urchin Supplemented with Calcium Promotes Mineralization in Saos-2 Human Bone Cell Line [PDF]
Marine Drugs, 2020 Polyhydroxylated naphthoquinones (PHNQs), known as spinochromes that can be extracted from sea urchins, are bioactive compounds reported to have medicinal properties and antioxidant activity.
Yakun Hou +9 more
doaj +2 more sources