Results 181 to 190 of about 12,985,405 (284)

Estimates and predictors of HIV viral non‐suppression in South African adults on antiretroviral treatment

Journal of the International AIDS Society, Volume 29, Issue 1, January 2026.
Abstract Introduction Viral suppression estimates are essential for monitoring the performance of HIV programmes. South Africa introduced dolutegravir (DTG)‐based antiretroviral therapy (ART) in 2019. We sought to generate updated estimates of viral suppression in South African adults on ART and investigate predictors of viral non‐suppression.
Haroon Moolla, Reshma Kassanjee, Jonathan Euvrard, Gary Maartens, Hans W. Prozesky, Matthew P. Fox, Catherine Orrell, Geoffrey Fatti, Frank Tanser, Gilles Wandeler, Mary‐Ann Davies, Renee de Waal, Patience Nyakato, Leigh F. Johnson, the International epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA‐SA) Collaboration   +14 more
wiley   +1 more source

Mitochondrial EFTs defects in juvenile-onset Leigh disease, ataxia, neuropathy, and optic atrophy

Neurology, 2014
S. Ahola, P. Isohanni, L. Euro, Virginia Brilhante, A. Palotie, H. Pihko, T. Lönnqvist, Tanita Lehtonen, J. Laine, H. Tyynismaa, A. Suomalainen   +10 more
semanticscholar   +1 more source

Nutritional Management in Severe Methylmalonic and Propionic Acidemias: How Much Medical Food Is Too Much?

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Methylmalonic acidemia (MMA) and propionic acidemia (PA) are inherited metabolic disorders affecting valine and isoleucine catabolism. Long‐term therapy mainly involves dietary protein restriction. An amino acid mixture (AAM, medical food) free of the precursor amino acids is frequently used, especially when protein intake does not reach World
Diane Margoses, Apolline Imbard, Clément Pontoizeau, Anaïs Brassier, Jean‐Baptiste Arnoux, Juliette Bouchereau, Claire‐Marine Bérat, Murielle Assoun, Claire Belloche, Sabine Dewulf, Sandrine Dubois, Bénédicte Samba, Aude Servais, Myriam Dao, Edouard Le Guillou, Amélie de Colnet, Chris Ottolenghi, Pascale de Lonlay, Jean‐François Benoist, Manuel Schiff   +19 more
wiley   +1 more source

Thiamine pyrophosphokinase deficiency causes a Leigh Disease like phenotype in a sibling pair: identification through whole exome sequencing and management strategies

Molecular Genetics and Metabolism Reports, 2014
Jamie L Fraser, A. Vanderver, Sandra Yang, Taeun Chang, Laura Cramp, G. Vezina, U. Lichter-Konecki, K. Cusmano-Ozog, Patroula Smpokou, K. Chapman, D. Zand   +10 more
semanticscholar   +1 more source

Energy Metabolism Under Stress: Late‐Stage Leigh Syndrome Reveals Profound Cardiometabolic Perturbations in Ndufs4 KO Mice

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
Cardiac bioenergetic and metabolic perturbations in late‐stage Leigh syndrome. Whole‐body NDUFS4 loss severely impairs cardiac complex I activity and respiration, shifting reliance to complex II and reducing glycolytic, TCA, and amino acid‐derived energy‐generating substrates in the heart.
Karin Terburgh, Nastassja Sweeney, Roan Louw   +2 more
wiley   +1 more source

Multiple Mitochondrial Dysfunction Syndrome Caused by IBA57 Gene Mutation: A Case Report and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
We report a novel IBA57 variant in a pediatric case, with pathogenicity confirmed through familial segregation analysis, Sanger sequencing, 3D protein modeling, and evolutionary conservation studies. Mitochondrial complex activity assays demonstrated functional impairment. A comprehensive review of literature further elucidates the genotypic‐phenotypic
Jia Xu, Xin Zhang, Ying Hua, Li Yang, Dongyu Shi, Shiyan Qiu   +5 more
wiley   +1 more source

Great Ape Childhoods: Social and Spatial Pathways to Independence in Bonobo and Chimpanzee Infants

Developmental Science, Volume 29, Issue 1, January 2026.
ABSTRACT Human development is marked by extended immaturity, necessitating extended care throughout infancy and childhood, facilitating advanced cognitive, social, and cultural skill acquisition. Parallels of extended development are also present in our closest living relatives, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes), which differ ...
Jolinde M. R. Vlaeyen, Bas van Boekholt, Franziska Wegdell, Raymond Katumba, Andreas Berghänel, Martin Surbeck, Simone Pika   +6 more
wiley   +1 more source

Exploring disciplinary perspectives on community resilience

Disasters, Volume 50, Issue 1, January 2026.
Abstract Throughout human history, communities have responded to challenges in urban and rural contexts by engaging multiple agents and actors, including individuals, institutions, and governments. Disciplinary expertise, including deep knowledge and practice, has contributed to economic, social, technological, and political change.
Alan Forster, Leigh‐Anne Hepburn, Liz Brogden, Megan Boston, Laurent Galbrun, Taibat Lawanson, Jolanda Morkel, Des Bernie   +7 more
wiley   +1 more source

Genetically and metabolically corrected pluripotent stem cells from patients with mtDNA disease [PDF]

, 2015
Ahmed, Riffat, Amato, Paula, Belmonte, Juan Carlos Izpisua, Folmes, Clifford DL, Gutierrez, Nuria Marti, Hayama, Tomonari, Huang, Taosheng, Kang, Eunju, Koski, Amy, Laurent, Louise C, Lee, Yeonmi, Li, Ying, Ma, Hong, Ma, Li, Mitalipov, Nargiz, Mitalipov, Shoukhrat, Mora-Castilla, Sergio, Morey, Robert, Ocampo, Alejandro, Poulton, Joanna, Terzic, Andre, Tippner-Hedges, Rebecca, Van Dyken, Crystal, Wang, Xinjian, Wolf, Don P, Wu, Jun   +25 more
core   +1 more source

Multi Perspective Considerations for Health Smart Home: Early Phase Exploratory Study

Journal of Advanced Nursing, Volume 82, Issue 1, Page 849-866, January 2026.
ABSTRACT Aims This study engaged key stakeholders—older adults, family caregivers, home care support workers, nurses, and home healthcare leaders—to explore perspectives on essential components and integration into home care models, and to explore the role of their technology readiness for health smart homes adoption.
Gordana Dermody, Rania Shibl, Mingzhong Wang, Andy Ward, Judy Watson, Kerry North, Jacqueline Blake, Erica Mealy, Abigail MY Koay, Sirinthip Roomkham, Phee Lep Yeoh, Roschelle Fritz   +11 more
wiley   +1 more source