American Journal of Surgical Pathology, 2019 Genetic alterations in uterine myxoid leiomyosarcoma are unknown. We investigate the clinicopathologic features of 19 uterine tumors previously diagnosed as myxoid leiomyosarcomas in which tumoral RNA was subjected to targeted RNA sequencing. PLAG1, BCOR,
J. Arias-Stella +11 more
semanticscholar +1 more source
Primary leiomyosarcoma of kidney: A rare case report
Muller Journal of Medical Sciences and Research, 2015 Primary leiomyosarcoma of kidney is extremely rare tumour accounting for 0.12% of renal tumours. Radiological investigations are not able to differentiate between leiomyosarcoma and sarcomatoid renal cell carcinoma.
Pooja Srivastava +2 more
doaj +1 more source
Trabectedin arrests a doxorubicin-resistant PDGFRA-activated liposarcoma patient-derived orthotopic xenograft (PDOX) nude mouse model. [PDF]
, 2018 BACKGROUND:Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed.
Dry, Sarah M +16 more
core +3 more sources
The Importance of the Study of the Hemodynamics of the Uterine Tumors by the Method of Dopplerometry in the Two- and Three-dimensional Echography Modes for Differential Diagnostics of Simple, Proliferating Leiomyomas and Uterine Sarcomas (Review of Litera [PDF]
, 2018 The article analyzes modern literature data on the importance of studying the hemodynamics of uterine tumors with dopplerometry in two - and three - dimensional regimens of echography for differential diagnosis of simple proliferating leiomyomas and ...
Sukhin, V. (Vladyslav) +3 more
core +2 more sources
Molecular biomarkers for uterine leiomyosarcoma and endometrial stromal sarcoma
Cancer Science, 2018 Uterine leiomyosarcoma (u‐LMS) and endometrial stromal sarcoma (ESS) are among the most frequent soft tissue sarcomas, which, in adults, lead to fatal lung metastases and patients have an extremely poor prognosis.
H. Tsuyoshi, Y. Yoshida
semanticscholar +1 more source
Anti-proliferative but not anti-angiogenic tyrosine kinase inhibitors enrich for cancer stem cells in soft tissue sarcoma. [PDF]
, 2014 BackgroundIncreasing studies implicate cancer stem cells (CSCs) as the source of resistance and relapse following conventional cytotoxic therapies. Few studies have examined the response of CSCs to targeted therapies, such as tyrosine kinase inhibitors ...
Ames, Erik +11 more
core +2 more sources
Journal of Clinical Oncology, 2018 PURPOSE We conducted a randomized phase III trial to determine whether adjuvant chemotherapy improves survival in women with uterine leiomyosarcoma.
M. Hensley +15 more
semanticscholar +1 more source
Primary urachal leiomyosarcoma: A rare case report and literature review
Urology Case Reports, 2022 Primary urachal leiomyosarcoma is rare entity with unclear prognosis and treatment strategy. We report a case of urachal leiomyosarcoma presenting, and treated with open urachal tumor resection and partial cystectomy.
Shijie Tong, Zhankui Jia
doaj
Diagnosis of Leiomyosarcoma after Uterine Artery Embolization for Multiple Leiomyomas
Case Reports in Obstetrics and Gynecology, 2020 Uterine sarcoma is significantly rarer than leiomyoma and has poor prognosis. Moreover, the diagnosis of leiomyosarcoma is difficult because its symptoms, including pelvic pain, uterine mass, and/or uterine bleeding, are very similar to those of ...
Maako Tsuji +5 more
doaj +1 more source
A patient-derived orthotopic xenograft (PDOX) mouse model of a cisplatinum-resistant osteosarcoma lung metastasis that was sensitive to temozolomide and trabectedin: implications for precision oncology. [PDF]
, 2017 In the present study, we evaluated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared to cisplatinum (CDDP) on a patient-derived orthotopic xenogrraft (PDOX) of a lung-metastasis from an osteosarcoma of a patient who failed CDDP therapy ...
Dry, Sarah M +15 more
core +1 more source