Results 31 to 40 of about 33,078 (232)

Leiomyosarcoma With Alternative Lengthening of Telomeres Is Associated With Aggressive Histologic Features, Loss of ATRX Expression, and Poor Clinical Outcome

, 2017
Leiomyosarcoma is an aggressive soft tissue sarcoma with poor patient survival. Recently, it was shown that 53% to 62% of leiomyosarcomas use the alternative lengthening of telomeres (ALT) as their telomere maintenance mechanism.
Liau, Jau-Yu;Tsai, Jia-Huei;Jeng, Yung-Ming;Lee, Jen-Chieh;Hsu, Hung-Han;Yang, Ching-Yao, 鄭永銘;李仁傑;蔡佳惠;楊卿堯;廖肇裕   +1 more
core   +1 more source

Clinical Efficacy of Vorinostat in a Patient with Leiomyosarcoma

, 2012
Leiomyosarcoma is a heterogeneous tumor group, representing
Colin McGuire, Jin Lee
core   +1 more source

Gastric Metastasis from a Primary Renal Leiomyosarcoma

Case Reports in Gastroenterology, 2012
Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools.
Satoshi Yodonawa, Isao Ogawa, Susumu Yoshida, Hiromichi Ito, Akinori Kato, Ryoko Kubokawa, Emika Tokoshima, Hiroaki Shimoyamada   +7 more
doaj   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

Treatment Outcomes in Osteosarcoma of the Head and Neck: A Systematic Review and Meta‐Analysis

Head &Neck, EarlyView.
ABSTRACT Background Head and neck osteosarcomas (HNOS) are rare, accounting for ~1% of head and neck malignancies. This study systematically evaluated the role of chemotherapy (CT) and radiotherapy (RT) on survival outcomes. Methods A systematic review and meta‐analysis were performed following PRISMA guidelines across six databases.
Angela Magri, Andrea Quaiattini, Alex Mlynarek, Keith Richardson, Michael Hier, Nader Sadeghi, Ramy Saleh, Ahmed Aoude, Khalil Sultanem, Salvatore Di Maio, Tamara Mijovic, Marco Mascarella, Emily Kay‐Rivest   +12 more
wiley   +1 more source

A potential diagnostic biomarker: Proteasome LMP2/b1i-differential expression in human uterus neoplasm [PDF]

, 2012
Uterine leiomyosarcoma (ULMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, the development of uterine ULMS
Nobuo Yaegashi, Akiko Horiuchi, Takuma Hayashi, Hiroyuki Aburatani, Susumu Tonegawa, Ikuo Konishi   +5 more
core  

Leiomyosarcoma of the breast [PDF]

Journal of Surgical Case Reports, 2011
Leiomyosarcomas of the breast are rare tumors. Less than 16 such cases have been reported in the literature so far. We present a case of a 44 year female patient who was found to have primary leiomyosarcoma of the breast.
Oktay, Y, Fikret, A
openaire   +2 more sources

Cutaneous Leiomyosarcoma of the Head and Neck: Appreciation of a More Indolent Biological Behavior and Implications for Its Management

Head &Neck, EarlyView.
ABSTRACT Background Leiomysosarcoma (LMS) is generally associated with high metastatic potential and poor survival. Cutaneous LMS (cLMS) has been considered a different entity with more indolent biological behavior. Methods A narrative review was performed to assess the biological behavior of cLMS, with special attention for the head and neck location.
Eelco de Bree, Remco de Bree, Carlos Chiesa‐Estomba, Orlando Guntinas‐Lichius, M. P. Sreeram, Dimosthenis Michelakis, Karthik N. Rao, Alessandra Rinaldo, Alfio Ferlito   +8 more
wiley   +1 more source

Primary leiomyosarcoma of epididymis: a case report

Journal of Medical Case Reports
Background Leiomyosarcoma is a tumor that can develop in any organ that contains smooth muscles. Although leiomyosarcoma is common, its epididymal localization is quite rare.
Hong-Jie Chen, Yao-dong Han, Dong-hai Li, Wu Li, Jun Zhang   +4 more
doaj   +1 more source