Results 121 to 130 of about 212,497 (330)

Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture

Molecular Ecology Resources, EarlyView.
ABSTRACT New approaches are urgently needed to enrich rare or low‐abundant DNA in complex samples. Soil‐transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of their host as adults and are excreted as eggs and larvae in faeces, complicating our understanding of their biology and the use of genetic tools ...
Marina Papaiakovou, Andrea Waeschenbach, Roy M. Anderson, Piet Cools, Zeleke Mekonnen, D. Timothy J. Littlewood, Cinzia Cantacessi, Stephen R. Doyle   +7 more
wiley   +1 more source

Cloning and expression of codon-optimized recombinant darbepoetin alfa in Leishmania tarentolae T7-TR [PDF]

, 2016
Darbepoetin alfa is an engineered and hyperglycosylated analog of recombinant human erythropoietin (EPO) which is used as a drug in treating anemia in patients with chronic kidney failure and cancer.
Fard-Esfahani, P., Golavar, R., Khajeniazi, S., Kianmehr, A., Mahrooz, A., Mostafavi, S.S., Oladnabi, M., Omidinia, E., Rouintan, M.   +8 more
core   +1 more source

Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites

Scientific Reports, 2015
Neutrophil extracellular traps (NETs) extruded from neutrophils upon activation are composed of chromatin associated with cytosolic and granular proteins, which ensnare and kill microorganisms. This microbicidal mechanism named classical netosis has been
N. C. Rochael, Anderson B. Guimarães-Costa, M. T. Nascimento, Thiago DeSouza-Vieira, Matheus P. Oliveira, Luiz F. Garcia e Souza, Marcus F. Oliveira, E. Saraiva   +7 more
semanticscholar   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Species structure of sand fly (Diptera: Psychodidae) fauna in the Brazilian western Amazon

Memorias do Instituto Oswaldo Cruz, 2009
We surveyed areas of the state of Rondônia in western Amazon for phlebotomine, which are potential vectors of leishmaniasis. A total of 5,998 specimens were captured, resulting in the identification of 48 species within the Lutzomyia (99.98%) and ...
Luiz Herman Soares Gil, Maisa da Silva Araújo, Juan Miguel Villalobos, Luis Marcelo Aranha Camargo, Luiz Shozo Ozaki, Cor Jesus Fernandes Fontes, Paulo Eduardo Martins Ribolla, Tony Hiroshi Katsuragawa, Rafael Mesquita Cruz, Alexandre de Almeida e Silva, Luiz Hildebrando Pereira da Silva   +10 more
doaj   +1 more source

Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures

mBio, 2016
Macrophages are mononuclear phagocytes that constitute a first line of defense against pathogens. While lethal to many microbes, they are the primary host cells of Leishmania spp.
M. C. Fernandes, Laura A. L. Dillon, A. Belew, H. C. Bravo, D. Mosser, Najib M. El-Sayed   +5 more
semanticscholar   +1 more source

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, EarlyView.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

Journal of Medical Microbiology and Infectious Diseases, 2016
Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and ...
Negar Seyed, Sima Rafati
doaj  

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Frontiers in Immunology
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases.
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi   +10 more
doaj   +1 more source

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance

F1000Research, 2016
Leishmania has a plastic genome, and drug pressure can select for gene copy number variation (CNV). CNVs can apply either to whole chromosomes, leading to aneuploidy, or to specific genomic regions.
Marie-Claude N. Laffitte, P. Leprohon, B. Papadopoulou, M. Ouellette   +3 more
semanticscholar   +1 more source