Results 101 to 110 of about 120,500 (221)

Natural Infection by Toscana Virus and Other Phleboviruses in Wild Sand Flies From Spain: Prevalence, Genetic Characterization and Tripartite Interactions With Leishmania infantum and Wolbachia

Zoonoses and Public Health, Volume 73, Issue 7, Page 655-669, November 2026.
ABSTRACT Introduction Toscana virus (TOSV) and Leishmania species are sand fly‐borne pathogens that pose a significant public health threat and an increasing risk of exposure in Europe. The objective of this study was to identify the phleboviruses circulating in an area endemic for sand fly‐borne pathogens and to estimate infection prevalence in wild ...
Andrés Torres‐Llamas, Antonio Sampedro, Victoriano Díaz‐Sáez, Manuel Morales‐Yuste, Javier Rodríguez‐Granger, Irene Pedrosa‐Corral, José María Navarro‐Marí, Francisco Morillas‐Márquez, Joaquina Martín‐Sánchez   +8 more
wiley   +1 more source

Exploring Bioinformatics Solutions for Improved Leishmaniasis Diagnostic Tools: A Review

Molecules
Significant populations in tropical and sub-tropical locations all over the world are severely impacted by a group of neglected tropical diseases called leishmaniases.
Natáli T. Capistrano Costa, Allana M. de Souza Pereira, Cibele C. Silva, Emanuelle de Oliveira Souza, Beatriz C. de Oliveira, Luiz Felipe G. R. Ferreira, Marcelo Z. Hernandes, Valéria R. A. Pereira   +7 more
doaj   +1 more source

Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Hit‐to‐lead optimization of morpholinephenylbenzamides reveals key structure–activity relationships against Trypanosoma cruzi and Leishmania infantum. Potency, selectivity, and ADME properties are differentially improved across the series, identifying compounds 20, 24, and 16 as complementary templates for the future design of dual antiparasitic leads.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan‐Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria dos Santos Carvalho, Eduardo Jorge Pilau, Izabela Marques Dourado Bastos, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Silvane Maria Fonseca Murta, Celso de Oliveira Rezende Júnior   +15 more
wiley   +1 more source

Species structure of sand fly (Diptera: Psychodidae) fauna in the Brazilian western Amazon

Memorias do Instituto Oswaldo Cruz, 2009
We surveyed areas of the state of Rondônia in western Amazon for phlebotomine, which are potential vectors of leishmaniasis. A total of 5,998 specimens were captured, resulting in the identification of 48 species within the Lutzomyia (99.98%) and ...
Luiz Herman Soares Gil, Maisa da Silva Araújo, Juan Miguel Villalobos, Luis Marcelo Aranha Camargo, Luiz Shozo Ozaki, Cor Jesus Fernandes Fontes, Paulo Eduardo Martins Ribolla, Tony Hiroshi Katsuragawa, Rafael Mesquita Cruz, Alexandre de Almeida e Silva, Luiz Hildebrando Pereira da Silva   +10 more
doaj   +1 more source

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +1 more source

Differential microRNA expression profiles and predicted miRNA–mRNA regulatory networks in human macrophage-like cells infected with Leishmania infantum

Scientific Reports
MicroRNAs (miRNAs) regulate gene expression and play a crucial role in numerous diseases, including infections. Leishmaniasis is a neglected infectious disease occurring in different forms (i.e., cutaneous, mucocutaneous, and visceral) caused by a ...
Aurora Diotallevi, Gloria Buffi, Sara Maestrini, Germano Castelli, Federica Bruno, Fabrizio Vitale, Luca Galluzzi   +6 more
doaj   +1 more source

Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts

Türkiye Parazitoloji Dergisi
Objective: Juniperus communis (J. communis) (common juniper) is a plant that has been used for medicinal purposes for centuries. This study aims to evaluate the antiparasitic effects of ethanol, methanol, chloroform, and water extracts of J.
İbrahim Çavuş, Yener Özel, Varol Tunalı, Hüsniye Kayalar, Kor Yereli, Ahmet Özbilgin   +5 more
doaj   +1 more source

Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey

Türkiye Parazitoloji Dergisi
Objective: Canine leishmaniasis (CanL) is an important veterinary and public health problem in Mediterranean countries. Although CanL and vector sandflies are widespread in the study area, there are no standardized diagnostic and treatment methods ...
Metin Pekağırbaş, Mehmet Karakuş, Elif Dönmez, Hüseyin Gökhan Özdemir, Yusuf Özbel, Seray Töz   +5 more
doaj   +1 more source

Manifestaciones tóxicas cardiovasculares con el uso de antimoniales en una paciente con leishmaniasis cutánea

Medicina U.P.B., 2019
La toxicidad por antimoniales tiene múltiples manifestaciones sistémicas, entre ellas, las alteraciones cardiovasculares son de las de mayor gravedad, que pueden, incluso, llevar a la muerte.
Adrián Valverde Legarda
doaj   +1 more source

Sialic Acid and Colchicine Functionalized Silica Nanoparticles: A Novel Approach to Leishmanicidal Selective Treatments

Biomedicines
Background/Objectives: Leishmaniasis remains a neglected tropical disease, with nearly one million new cases annually and limited investment in research.
Adan Jesus Galue-Parra, Sandra Jimenez-Falcao, Esther Arribas-Yuste, Clotilde Marin, Jose Manuel Mendez-Arriaga   +4 more
doaj   +1 more source