Results 91 to 100 of about 172,432 (281)

An Unusual Presentation of Cutaneous Leishmaniasis in a Patient with Substance Use: A Diagnostic and Management Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT In patients with atypical ulcers and travel history to endemic areas, a comprehensive diagnostic workup for cutaneous leishmaniasis is imperative. This case confirms Leishmania tropica through combined microscopy, culture, and PCR, leading to successful treatment with systemic glucantime and adjunctive wound care.
Hossein Pazoki, Eissa Soleymani, Shirafkan Kordi, Mahdi Fakhar   +3 more
wiley   +1 more source

Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design

Journal of Medical Microbiology and Infectious Diseases, 2016
Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and ...
Negar Seyed, Sima Rafati
doaj  

Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites. [PDF]

, 2011
Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and ...
Bauer, Holger, Brückner, Margit, Davioud-Charvet, Elisabeth, Deregnaucourt, Christiane, Jannack, Beate, Johann, Laure, Lanfranchi, Don Antoine, Lanzer, Michael, Müller, Tobias, Sanchez, Cecilia, Schirmer, R Heiner, Schrével, Joseph, Yardley, Vanessa   +12 more
core   +2 more sources

Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geographic distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil.
Camila C. Bitencourt Brito, Hélder Vinicius Carneiro da Silva, Daci José Brondani, Antonio Rodolfo de Faria, Rafael Matos Ximenes, Ivanildo Mangueira da Silva, Julianna F. C. de Albuquerque, Marcelo Santos Castilho   +7 more
doaj   +1 more source

Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia [PDF]

, 2009
We conducted a case-control study to evaluate risk factors for visceral leishmaniasis during an epidemic in a previously unaffected district of Ethiopia. We also collected blood and bone marrow specimens from dogs in the outbreak villages.
Alvar, Jorge, Aparicio, Pilar, Argaw, Daniel, Bashaye, Seife, Bern, Caryn, Cañavate, Carmen, Chicharro, Carmen, Herrero, Merce, Mulugeta, Abate, Nieto, Javier, Nombela, Nohelly, Vélez, Iván Darío   +11 more
core   +1 more source

In Vitro Evaluation of Antileishmanial Activity of Commiphora myrrha Essential Oil Nanoliposome

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
This study investigates the efficacy of nanoliposomal formulations containing myrrh essential oil in combating Leishmania protozoa in laboratory settings. Myrrh essential oil and nanoliposomes were prepared in RPMI‐1640 medium at concentrations of 1, 2, 5 and 10 µg/dL.
Zahra Akbari, Mohammad Reza Youssefi, Mohaddeseh Abouhosseini Tabari   +2 more
wiley   +1 more source

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Frontiers in Immunology
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases.
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi   +10 more
doaj   +1 more source

Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

Iranian Journal of Parasitology, 2021
Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu, Rhuan Carlos Souza Caetano, Kárin Rosi Reinhold-Castro, Manoel Sebastião da Costa Lima-Junior, Wagner José Tenório dos Santos, Gessilda de Alcantara Nogueira de Melo, Roberto Kenji Nakamura Cuman, Sandra Mara Alessi Aristides, Thais Gomes Verzignassi Silveira, Maria Valdrinez Campana Lonardoni   +9 more
doaj  

A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules [PDF]

Exploration of Drug Science
Leishmanial diseases, caused by various species of the protozoan parasite Leishmania, continue to pose a significant global health challenge. Medicinal drugs have been at the forefront of combating these diseases, offering hope for afflicted populations.
Tejaswini Masne, Dileep Kumar, Deepali Bansode   +2 more
doaj   +1 more source

Management of trypanosomiasis and leishmaniasis [PDF]

, 2012
<p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford, Alvar, Alvar, Barrett, Barrett, Ben Salah, Berman, Bern, Brun, Brun, Burri, Chappuis, Coura, Croft, Croft, El-Sayed, Frearson, Hailu, Jacobs, Jacobs, Le Loup, Lessa, M. P. Barrett, Miranda-Verastegui, Paine, Pinazo, Priotto, Rassi, Reithinger, Rodgers, S. L. Croft, Stuart, Sundar, Sundar, Sundar, Sundar, Torreele, Vanhollebeke, Vincent, Voogd   +39 more
core   +2 more sources