Results 71 to 80 of about 57,558 (196)
Frontiers in ImmunologyBackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases.
Shima Hadifar +10 more
doaj +1 more source
Iranian Journal of Parasitology, 2021 Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice.
Herintha Coeto Neitzke-Abreu +9 more
doaj
A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules [PDF]
Exploration of Drug ScienceLeishmanial diseases, caused by various species of the protozoan parasite Leishmania, continue to pose a significant global health challenge. Medicinal drugs have been at the forefront of combating these diseases, offering hope for afflicted populations.
Tejaswini Masne +2 more
doaj +1 more source
Trends in Parasitology, 2006 The observation that differentiation of parasite life cycle stages involves structural and functional reorganisation is very familiar. A recent paper by Besteiro and colleagues provides an intriguing insight into cellular remodelling during differentiation.
openaire +2 more sources
Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights
ChemistrySelect, Volume 11, Issue 29, 3 August 2026.Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva +16 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyBackgroundCutaneous leishmaniasis (CL), caused by Leishmania (L.) species, remains a neglected tropical disease in many developing countries. We and others have shown that different Leishmania species can alter the gene expression profile of human host ...
Shima Hadifar +10 more
doaj +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.This work highlights the satisfactory pharmacokinetic profile of two benzenesulfonylpiperazine lead candidates, followed by in vivo assessment in a murine model of visceral leishmaniasis. This assessment identified compound 2 as moderately active at a lower dose, but its efficacy increased at higher doses, though with concerns regarding safety.
Thibault Joseph William Jacques Dit Lapierre +13 more
wiley +1 more source
Exploring Bioinformatics Solutions for Improved Leishmaniasis Diagnostic Tools: A Review
MoleculesSignificant populations in tropical and sub-tropical locations all over the world are severely impacted by a group of neglected tropical diseases called leishmaniases.
Natáli T. Capistrano Costa +7 more
doaj +1 more source
Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies
Journal of Applied Entomology, Volume 150, Issue 7, Page 990-1015, August 2026.ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi +4 more
wiley +1 more source
Species structure of sand fly (Diptera: Psychodidae) fauna in the Brazilian western Amazon
Memorias do Instituto Oswaldo Cruz, 2009 We surveyed areas of the state of Rondônia in western Amazon for phlebotomine, which are potential vectors of leishmaniasis. A total of 5,998 specimens were captured, resulting in the identification of 48 species within the Lutzomyia (99.98%) and ...
Luiz Herman Soares Gil +10 more
doaj +1 more source