Results 61 to 70 of about 120,500 (221)

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Studies on immunology of Leishmania mexicana [PDF]

, 2007
Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects.
Rezvan, H, Rezvan, Hossein
core  

A real-time PCR assay to estimate Leishmania chagasi load in its natural sand fly vector Lutzomyia longipalpis. [PDF]

, 2008
Leishmania chagasi, transmitted mainly by Lutzomyia longipalpis sand flies, causes visceral leishmaniasis and atypical cutaneous leishmaniasis in Latin America.
Ranasinghe, Shalindra, Ranasinghe, S., Rogers, Matthew E., Hamilton, J. G. C., Maingon, Rhayza DC, Rogers, Matthew E, Bates, Paul, Hamilton, James GC, Maingon, R. D. C., Bates, Paul A   +9 more
core   +1 more source

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

Detection of Leishmania RNA Virus in Leishmania Parasites

PLoS Neglected Tropical Diseases, 2013
BACKGROUND Patients suffering from cutaneous leishmaniasis (CL) caused by New World Leishmania (Viannia) species are at high risk of developing mucosal (ML) or disseminated cutaneous leishmaniasis (DCL). After the formation of a primary skin lesion at the site of the bite by a Leishmania-infected sand fly, the infection can disseminate to form ...
Zangger, Haroun, Ronet, Catherine, Desponds, Chantal, Kuhlmann, F. Matthew, Robinson, John, Hartley, Mary-Anne, Prevel, Florence, Castiglioni, Patrik, Pratlong, Francine, Bastien, Patrick, Müller, Norbert, Parmentier, Laurent, Saravia, Nancy Gore, Beverley, Stephen, Fasel, Nicolas   +14 more
openaire   +11 more sources

Production of Recombinant Leishmania Tropica Parasites Expressing Two Proteins of Egfp and Luciferase Reporter

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2017
BACKGROUND AND OBJECTIVE: L. tropica is the major cause of cutaneous and visceral leishmaniasis in Iran. Due to lack of an accurate, sensitive and noninvasive detection test in animal model is a major problem. Here, we designed L.
T Taheri, M Eskandar, S Rafati
doaj  

Systemic treatment of cutaneous leishmaniasis: A systematic review and meta‐analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This systematic review and meta‐analysis assessed systemic treatments for cutaneous leishmaniasis across 83 studies and 4603 patients. Treatment efficacies of meglumine antimoniate, miltefosine, azoles, pentamidine, and liposomal amphotericin B varied by region and species. Miltefosine showed consistent evidence across multiple settings.
Maximilian Egg, Dennis Wienand, Lucie Harpain, Marie‐Luise Brunner‐Kovarik, Julia Walochnik, Markus Wiesmueller, Amélie Hampel, Tibor Spath, Lukas Trnka, Judit Simon, Alessandra Handisurya   +10 more
wiley   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Turner Nicholas J., Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Blake, D.G., Malcolm D Walkinshaw, Thomson, G.   +48 more
core   +2 more sources

PUF Proteins as Critical RNA-Binding Proteins in TriTryp Parasites: A Review Article

Iranian Journal of Parasitology
In eukaryotes, translation is a fundamental step in the long pathway of protein synthesis within the cell. In this process, several proteins and factors have involved directly or indirectly, individually or in association with other elements to contact ...
Tahereh Taheri, Elaheh Davarpanah, Katayon Samimi-Rad, Negar Seyed   +3 more
doaj   +1 more source

Retrospective evaluation of outcomes in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban as a sole or adjunctive thromboprophylaxis agent: 34 cases (2018‐2024)

Journal of Small Animal Practice, EarlyView.
Objectives To describe clinical outcomes, thromboembolic and haemorrhagic complications, and treatment characteristics in dogs with non‐associative immune‐mediated haemolytic anaemia treated with rivaroxaban at a UK referral hospital. Materials and Methods Retrospective descriptive study of dogs diagnosed with non‐associative immune‐mediated haemolytic
S. Conway, L. Jenkins, J. Reeve
wiley   +1 more source