Results 51 to 60 of about 120,500 (221)

Current Status of Regulatory Non-Coding RNAs Research in the Tritryp

Non-Coding RNA, 2022
Trypanosomatids are protozoan parasites that cause devastating vector-borne human diseases. Gene expression regulation of these organisms depends on post-transcriptional control in responding to diverse environments while going through multiple ...
Rafael Sebastián Fort, Santiago Chavez, Juan M. Trinidad Barnech, Carolina Oliveira-Rizzo, Pablo Smircich, José Roberto Sotelo-Silveira, María Ana Duhagon   +6 more
doaj   +1 more source

Survey of the health and welfare of imported dogs presenting to UK veterinary surgeons

Veterinary Record, EarlyView.
Abstract Background Since changes to legislation in 2012, numbers of dogs imported into the UK, especially rescues, have increased substantially. We aimed to explore the health and behaviour issues among imported dogs presented to UK veterinary surgeons. Methods An online survey was completed by 413 veterinary surgeons practising in the UK in 2023. The
Gina Pinchbeck, Robyn Lyne, Lisa Wallis, Jenny Stavisky, Robert Christley, Louise Buckley, Carri Westgarth   +6 more
wiley   +1 more source

RNA synthesis in Leishmania donovani is constitutive during stage conversion: a genome-wide PRO-seq analysis

Microbiology Spectrum
Transcription in Leishmania donovani has long been considered constitutive, as shown by nuclear run-on analyses and northern blots, with gene expression primarily regulated post-transcriptionally.
Janne Grünebast, Stephan Lorenzen, Christine Brinker, Annika Bea, Joachim Clos   +4 more
doaj   +1 more source

Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding [PDF]

Open Biology, 2017
The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology.
Jack Sunter, Keith Gull
doaj   +1 more source

Predicting Mammal Species Suitable for Chagas Disease Spread Using a Machine‐Learning Framework

Integrative Zoology, EarlyView.
Chagas disease is maintained in wildlife by Trypanosoma cruzi cycling among many mammal species, but we still do not know the full range of potential hosts. Using machine learning and ecological/behavioral traits, we found that kissing bugs overlap with 573 mammal species and tend to feed on mammals that are den‐dwelling, medium‐to‐large in size, and ...
Maya Rocha‐Ortega, Carezza Botto‐Mahan, Gemma Rojo, Alex Córdoba‐Aguilar   +3 more
wiley   +1 more source

Resolution and pro-resolving lipid mediators in Leishmania infection

Journal of Medical Microbiology and Infectious Diseases, 2019
The acute inflammatory response is the body’s natural reaction to inciting stimuli including trauma and pathogens. Well-known pro-inflammatory metabolites take control of this reaction to recruit the leukocytes into the inflamed tissue.
Negar Seyed, Sima Rafati
doaj  

Lactococcus lactis as a Live-Vector Vaccine Platform for Parasitic Diseases

Journal of Medical Microbiology and Infectious Diseases
The development of expression systems using non-pathogenic microorganisms has enabled efficient and safe platforms for medical and food applications, including functional foods with therapeutic benefits. Among non-pathogenic bacteria, Lactococcus lactis (
Elaheh Davarpanah, Negar Seyed, Tahereh Taheri *   +2 more
doaj   +1 more source

Common pathways and outliers in glucose catabolism across Trypanosomatidae

The FEBS Journal, EarlyView.
Trypanosomatid parasites, including Trypanosoma sp., Leishmania sp., Phytomonas sp., and Vickermania sp., share a common motif: a metabolism built around the glycosome, a unique peroxisome‐derived organelle housing the first steps of glycolysis. Yet, these organisms have evolved remarkably diverse strategies to catabolize glucose, excreting distinct ...
Fred R. Opperdoes, Mayke B. Alencar, Ariel M. Silber, Ingrid Škodová‐Sveráková, Kristína Záhonová, Vyacheslav Yurchenko   +5 more
wiley   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

The FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva, Thiago Vargas Seraphim, Karine Minari, Izabella Rodrigues Fonseca da Silva, Winston Pinheiro Claro Gomes, Leijiane Figueira de Sousa, Arthur Moraes Franco da Rocha, Leandro Ramos Souza Barbosa, Jeremiah Stanson Joseph, Júlio César Borges   +9 more
wiley   +1 more source

Evaluating the effect of immunization with DNA encoding Phlebotomus sergenti apyrase protein (PsSP42) against Leishmania tropica infection in BALB/c mouse model

Parasites & Vectors
Background Leishmania parasites are transmitted through the bite of infected female sand flies. The sand fly inoculum contains both the parasite and the salivary proteins, which can modulate the immune system’s function.
Samira Hosseinpour Jahednia, Hossein Rezvan, Hamzeh Sarvnaz, Sima Habibzadeh, Alireza Nourian, Tahereh Taheri, Negar Seyed, Elham Gholami, Sima Rafati   +8 more
doaj   +1 more source