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Leishmaniases are neglected diseases, caused by intracellular protozoan parasites of the Leishmania (L.) genus. Although the principal host cells of the parasites are macrophages, neutrophils are the first cells rapidly recruited to the site of parasites
Rafeh Oualha+5 more
semanticscholar +1 more source
Background: Visceral leishmaniasis (VL) is a systemic parasitic disease with diverse clinical manifestations, primarily affecting the spleen, liver, and bone marrow. While renal involvement in VL is well documented, it is often mild and resolves with effective treatment.
Ali Mansoursamaei+3 more
wiley +1 more source
Several intracellular Leishmania antigens have been identified in order to find a potential vaccine capable of conferring long lasting protection against Leishmania infection. Histones and Acid Ribosomal proteins are already known to induce an effective immune response and have successfully been tested in the cutaneous leishmaniasis mouse model.
Lais Pereira+12 more
openaire +7 more sources
Tissue Cytokine Responses in Canine Visceral Leishmaniasis [PDF]
To elucidate the local tissue cytokine response of dogs infected with Leishmania chagasi, cytokine mRNA levels were measured in bone marrow aspirates from 27 naturally infected dogs from Brazil and were compared with those from 5 uninfected control ...
Courtenay, O.+6 more
core +2 more sources
Background:Trypanosoma caninum presents aflagellar and flagellar epimastigote, trypomastigote, and spheromastigote forms in axenic cultures. Attempts to utilize trypomastigote forms of T. caninum to develop in vitro and in vivo infection models have failed. To investigate the infection potential of aflagellar epimastigotes, T.
Kátia Cristina Silva Nascimento+9 more
wiley +1 more source
Biological activities and chemical composition of methanolic extracts of selected Autochthonous microalgae strains from the Red Sea [PDF]
Four lipid-rich microalgal species from the Red Sea belonging to three different genera (Nannochloris, Picochlorum and Desmochloris), previously isolated as novel biodiesel feedstocks, were bioprospected for high-value, bioactive molecules.
Carolina Bruno De Sousa+14 more
core +4 more sources
Promastigotes of Leishmania infantum undergo a series of extracellular developmental stages inside the natural sand fly vector Lutzomyia longipalpis to reach the infectious stage, the metacyclic promastigote.
Iliano V. Coutinho-Abreu+5 more
semanticscholar +1 more source
In Morocco, Leishmania infantum species is the main causative agents of visceral leishmaniasis (VL). However, cutaneous leishmaniasis (CL) due to L. infantum has been reported sporadically. Moreover, the recent geographical expansion of L.
M. Hakkour+8 more
semanticscholar +1 more source
Transmission potential of paromomycin-resistant Leishmania infantum and Leishmania donovani
AbstractObjectivesFormer studies demonstrated quick selection of paromomycin resistance for Leishmania infantum and Leishmania donovani accompanied by increased fitness. The present study aimed to interpret these findings in an epidemiological context by comparing infection of WT and experimentally derived paromomycin-resistant strains in the sand fly ...
G Caljon+6 more
openaire +3 more sources
Miltefosine induces metacaspase and PARP genes expression in Leishmania infantum
Objectives: Apoptosis is the process of programmed cell death (PCD) that occurs in both animal and plant cells. Protozoan parasites possess metacaspase and these caspase-related proteases could be involved in the PCD pathways in these organisms ...
Shahram Khademvatan+2 more
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