Results 1 to 10 of about 773 (150)

Whole-Genome Sequencing and Comparative Genomic Analysis of Leishmania (Viannia) naiffi and L. (Viannia) shawi Reveal Species-Specific Genes and Novel Potential Drug Targets [PDF]

Microorganisms
This study presents the complete sequencing and comparative genomic analysis of Leimania (Viannia) naiffi and Leishmania (Viannia) shawi, species of epidemiological relevance in the Brazilian Amazon.
Fabiano Reis da Silva, Lucas George Assunção Costa, Edivaldo Costa Sousa Junior, Walter Souza Santos, Lourdes Maria Garcez   +4 more
doaj   +2 more sources

Resequencing and De Novo Assembly of Leishmania (Viannia) guyanensis from Amazon Region: Genome Assessment, Phylogenetic Insights and Therapeutic Targets [PDF]

Pathogens
Leishmania guyanensis is one of 15 American human-pathogenic species, frequently linked to therapeutic failure due to its marked genetic plasticity and adaptability under drug pressure. To broaden the genomic understanding of this species, its biological
Lucas George Assunção Costa, Edivaldo Costa Sousa Junior, Camila Cristina Cardoso, Millena Arnaud Franco da Igreja, Franklyn Samudio Acosta, Fabiano Reis da Silva, Lourdes Maria Garcez   +6 more
doaj   +2 more sources

Susceptibility of Lutzomyia longipalpis (Lutz & Neiva, 1912) to Fludora FusionPM, a combination of clothianidin and deltamethrin: field and laboratory bioassays [PDF]

Parasites & Vectors
Background Insecticides remain a cornerstone in the control of vector-borne diseases. In Brazil, Alfatek 200SC—a pyrethroid (alphacypermethrin)—is recommended for controlling phlebotomine sand flies, the vectors of leishmaniases.
Greicielly Barbosa Santos Silva, Josiane Valadão Lopes, Grasielle Caldas D’ Ávila Pessoa, Leticia Cavalari Pinheiro, João Paulo dos Santos, Fabiana Oliveira Lara-Silva, Nadja Biondine Marriel, Liléia Gonçalves Diotaiuti, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias   +9 more
doaj   +2 more sources

Low Plasma Lipids Are Associated with Relapsing and Lethal Visceral Leishmaniasis in HIV-Infected Patients [PDF]

Pathogens
Visceral leishmaniasis (VL) results from protozoa Leishmania infantum and L. donovani infection. This study investigated whether host factors would explain the relapses. First, susceptibility to amphotericin B of L.
Renata V. S. Silva, Silvia R. B. Uliana, Jenicer K. U. Y. Yasunaka, Cláudio S. Veloso, Emille Sousa, Maria M. L. Ferreira, Vivianne S. Carvalho, Gabriel R. Ferreira, Dorcas L. Costa, Carlos H. N. Costa   +9 more
doaj   +2 more sources

Revisiting Leishmania (Viannia) lainsoni Silveira, Shaw, Braga, and Ishikawa, 1987: current knowledge and emerging perspectives [PDF]

Parasites & Vectors
More than three decades after its description, Leishmania (Viannia) lainsoni Silveira, Shaw, Braga, and Ishikawa, 1987 remains the least explored species of the subgenus Viannia Lainson and Shaw, 1987 within the genus Leishmania Ross, 1903. Although long
Thais Gouvea de Morais, Marliane Batista Campos, Fernando Tobias Silveira, Thiago Vasconcelos dos Santos   +3 more
doaj   +2 more sources

Saúde, ciência e desenvolvimento: a emergência da leishmaniose tegumentar americana como desafio médico-sanitário no Amazonas [PDF]

História, Ciências, Saúde: Manguinhos, 2020
Resumo O artigo faz análise histórica da emergência da leishmaniose tegumentar americana como objeto do conhecimento e desafio médico-sanitário no Amazonas desde a década de 1970.
Cláudio de Oliveira Peixoto
doaj   +3 more sources

Insights from Leishmania (Viannia) guyanensis in vitro behavior and intercellular communication

Parasites & Vectors, 2021
Background Pentavalent antimonial-based chemotherapy is the first-line approach for leishmaniasis treatment and disease control. Nevertheless antimony-resistant parasites have been reported in some endemic regions. Treatment refractoriness is complex and
Luiza O. R. Pereira, Cíntia S. Sousa, Hellen C. P. Ramos, Eduardo C. Torres-Santos, Liliane S. Pinheiro, Marcelo R. Alves, Patricia Cuervo, Gustavo A. Sierra Romero, Mariana C. Boité, Renato Porrozzi, Elisa Cupolillo   +10 more
doaj   +1 more source

Studying nanotoxic effects of CdTe quantum dots in Trypanosoma cruzi

Memorias do Instituto Oswaldo Cruz, 2011
Semiconductor nanoparticles, such as quantum dots (QDs), were used to carry out experiments in vivo and ex vivo with Trypanosoma cruzi. However, questions have been raised regarding the nanotoxicity of QDs in living cells, microorganisms, tissues and ...
Cecilia Stahl Vieira, Diogo Burigo Almeida, André Alexandre de Thomaz, Rubem Figueredo Sadok Menna-Barreto, Jacenir Reis dos Santos-Mallet, Carlos Lenz Cesar, Suzete Araujo Oliveira Gomes, Denise Feder   +7 more
doaj   +1 more source

Malnutrition Aggravates Alterations Observed in the Gut Structure and Immune Response of Mice Infected with Leishmania infantum

Microorganisms, 2021
Malnutrition is a risk factor for developing visceral leishmaniasis and its severe forms. Our group demonstrated that malnourished animals infected with Leishmania infantum had severe atrophies in lymphoid organs and T cell subpopulations as well as ...
Felipe Gaitán-Albarracín, Monica Losada-Barragán, Nathalia Pinho, Renata Azevedo, Jonathan Durães, Juan Sebastián Arcila-Barrera, Rodrigo C. Menezes, Fernanda N. Morgado, Vinicius de Frias Carvalho, Adriana Umaña-Pérez, Patricia Cuervo   +10 more
doaj   +1 more source

Detection of amastigotes and histopathological alterations in the thymus of Leishmania infantum‐infected dogs

Immunity, Inflammation and Disease, 2020
Introduction In canine visceral leishmaniasis (CVL), lymphopenia, and the disorganization of lymphoid organs such as spleen and lymph nodes have been demonstrated. However, the involvement of thymus in CVL has not been evaluated so far.
Aurea V. A. daSilva, Tainã L. deSouza, Fabiano B. Figueiredo, Artur A. V. Mendes Jr., Luiz C. Ferreira, Camila P. B. Filgueira, Patricia Cuervo, Renato Porrozzi, Rodrigo C. Menezes, Fernanda N. Morgado   +9 more
doaj   +1 more source