Results 61 to 70 of about 689,229 (249)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

First record of saw-belly (Hemiculter leucisculus Basilewsky, 1855) from Zarinehrud River, Urmia Lake basin and its some biological characteristics [PDF]

بوم‌شناسی آبزیان, 2015
This study aimed to the first report of Saw-belly, Hemiculter leucisculus from the Zarinehrud River and investigation of its morphometric and meristic characteristics, length-weight and length-length relationships.
Alireza Radkhah, Soheil Eagderi
doaj  

Spatial and temporal variation in population structure of Hemigrammus marginatus (Characiformes: Characidae) in streams of the Ivinhema River Basin, Brazil

Zoologia (Curitiba), 2012
The present study has assessed spatial and temporal variations in the length structure of Hemigrammus marginatus Ellis, 1911 and estimated growth parameters for the species.
Luzia da Silva Lourenço, Izaias Médice Fernandes, Yzel Rondon Súarez   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Relationship between live weight and body condition score in Irish Holstein-Friesian dairy cows [PDF]

, 2011
peer-reviewedThe objective of this study was to quantify the change in live weight (LWT) per unit change in body condition score (BCS) for Irish Holstein-Friesian dairy cows. Mixed model analyses were performed on 82 948 test-day records of BCS and LWT
P. Dillon, D. P. Berry, F. Buckley, Buckley, Frank, Dillon, Pat, Berry, Donagh   +5 more
core  

Length-weight and length-length relationships, Relative condition factor and Fulton’s condition factor of Five Cyprinid species in Anzali wetland, southwest of the Caspian Sea

Caspian Journal of Environmental Sciences, 2012
This study was conducted to determine length-weight and length-length relationships, relative condition factor (Krel) and Fulton’s condition factor (K) for five species including Scardinius erythrophtalmus, Carassius auratus gibelio, Cyprinus carpio ...
Moradinasab, Gh., Daliri, M., Ghorbani, R., Paighambari, S.Y., Davoodi, R.   +4 more
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Relationships between cord blood leptin and ghrelin levels, milk intake and weight gain in human infants [PDF]

, 2003
Leptin and ghrelin are hormones involved in the regulation of appetite and adiposity. Leptin suppresses appetite and induces weight loss; ghrelin stimulates appetite and promotes weight gain.
James, Rachel J. A., James, Rachel J A
core