Results 51 to 60 of about 1,280,703 (249)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Length-Weight Relationships for Thirty Fish Species in Lake Niushan, a Shallow Macrophytic Yangtze Lake in Chin

Asian Fisheries Science, 2007
Length-weight relationships are presented for 30 fish species captured from April 2002 to January 2004 in Lake Niushan, China. The values of the exponent b in the length-weight relationships (W=aLb) ranged from 2.845 to 3.435 and the median of b was 3 ...
S. YE, Z. LI, G. FENG, W. CAO
doaj   +1 more source

Relationship between fish size and otolith length for 63 species of fishes from the Eastern North Pacific Ocean [PDF]

, 2000
Otoliths commonly are used to determine the taxon, age, and size of fishes. This information is useful for population management, predator-prey studies, and archaeological research.
Harvey, James T., Loughlin, Thomas R., Oxman, Dion S., Perez, Michael A.   +3 more
core  

Length–weight and length–length relationships of five fish species collected from seagrass beds of the Sungai Pulai estuary, Peninsular Malaysia [PDF]

, 2008
Length–weight relationships are presented for five fish species from the seagrass beds of Peninsular ...
Arshad, Aziz, Bujang, Japar Sidik, Jimmy, A., Nurul Amin, Sarker Mohammad, Zakaria @ Ya, Muta Harah   +4 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study [PDF]

, 2014
OBJECTIVES: Transgenerational effects of different environmental exposures are of major interest, with rodent experiments focusing on epigenetic mechanisms. Previously, we have shown that if the study mother is a non-smoker, there is increased mean birth
Golding, Jean, Gregory, Steven, Miller, Laura L, Northstone, Kate, Pembrey, Marcus   +4 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Length-weight relationships of Cuban marine fishes [PDF]

, 1997
A total of 140 sets of parameters (a and b) of the length-weight relationships (LWR) of the form W=aL super(b) are presented for fishes caught in Cuban waters. These parameters cover 94 species of fish belonging to 43 families.
Claro, R., Garcia-Arteaga, J.P., Valle, S.   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Bayesian approach for estimating length-weight relationships in fishes [PDF]

, 2014
A Bayesian hierarchical approach is presented for the estimation of length-weight relationships (LWR) in fishes. In particular, estimates are provided for the LWR parameters a and b in general as well as by body shape.
Carlander, Carlander, Clark, Froese, Gelman, Gelman, Jellyman, Kuikka, Peters, Pulkkinen, Spencer   +10 more
core   +1 more source