Results 61 to 70 of about 1,288,349 (249)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Length-Weight Relationships, Maturity, and Reproductive Season of the Fringelip Mullet Crenimugil crenilabis (Forsskål, 1775) from the Arabian Sea Coast of Oman

Journal of Agricultural and Marine Sciences, 2008
Fringelip mullet (Crenimugil crenilabis) caught at Al Duqum and Salalah in the Arabian  Sea region of Omanwere sampled monthly between January 2001 and December 2002.
Abdullah Al-Nahdi, Abdulaziz Al-Marzouqi, Said Al-Shajibi, Ahmed Al-Hosni   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Length-weight relationships of Hyperopisus bebe occidentalis in Zaria Dam [PDF]

, 2013
The morphometric parameters of 54 Hyperopisus hebe occidentalis obtained from Zaria Dam were investigated. The length occidentalis examined ranged from 18.9-41.0 cm and weight ranged from 25-425g, the largest male weighed 175g while the female was 425g ...
Abubakar, Y., Adeyemi, O., Onimisi, H.U.
core  

Studies on length-weight and length-length relationships of a catfish Eutropiichthyes vacha Hamilton (Schilbeidae: Silurifo)

Caspian Journal of Environmental Sciences, 2007
Present study describes the length-weight (LWR) and length-length (LLR) relationships of a freshwater catfish Eutropiichthyes vacha Hamilton from Indus River, Sindh, Pakistan. A total of 281 specimen of E. vacha were collected from fisherman?s catch from
Soomro, A.N., Baloch, W.A., Jafri, S.I.H., Suzuki, H.   +3 more
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Length-weight relationships of commercially important marine fishes and shellfishes of the southern coast of Karnataka, India [PDF]

, 2004
The parameters of the length-weight relationship of the form W = aLb are presented for 51 species of commercially important marine fishes and shellfishes caught along the southern coast of Karnataka, India.
Abdulrahiman, K.P., Harishnayak, T., Mohamed, K.S., Zacharia, P.U.   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Growth and maturity of salmon sharks (Lamna ditropis) in the eastern and western North Pacific, and comments on back-calculation methods [PDF]

, 2006
Age and growth estimates for salmon sharks (Lamna ditropis) in the eastern North Pacific were derived from 182 vertebral centra collected from sharks ranging in length from 62.2 to 213.4 cm pre-caudal length (PCL) and compared to previously published age
Goldman, Kenneth J., Musick, John A.
core   +1 more source