Results 121 to 130 of about 1,409,618 (315)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Association of day length and weather conditions with physical activity levels in older community dwelling people [PDF]

, 2014
Background: Weather is a potentially important determinant of physical activity. Little work has been done examining the relationship between weather and physical activity, and potential modifiers of any relationship in older people. Wetherefore examined
McMurdo, Marion E. T., Falko F Sniehotta, Donnan, Peter T, Vadiveloo, Thenmalar, Miles D Witham, Crombie, Iain K, Witham, Miles D, Crombie, Iain K., McMurdo Marion E. T., Witham, Miles D., Donnan Peter T., Vadiveloo Thenmalar, Sniehotta Falko F., Sniehotta, Falko F., Donnan, Peter T.; id_orcid, Feng Zhiqiang, McMurdo, Marion E T, Iain K Crombie, Peter T Donnan, Crombie Iain K., Marion E T McMurdo, Thenmalar Vadiveloo, Feng, Zhiqiang, Sniehotta, Falko F, Zhiqiang Feng, Witham Miles D.   +25 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Survival Analysis in Tourism Demand: The length of stay in Latin American destinations [PDF]

This article analyses the determinants of the length of stay of Portuguese tourists taking vacations in Latin America, based on a questionnaire distributed on flights of a Portuguese charter airline, Air Luxor.
Carlos Pestana Barros, Antónia Correia
core  

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Relationship between occlusal vertical dimension and linear ear length

Revista Cubana de Estomatología, 2020
Introduction: When occlusal vertical dimension becomes altered, as is sometimes the case, use should be made of subjective and objective methods, including those based on an anthropometric approach. Objective: Evaluate the correlation between linear ear
Elizabeth Julcamoro Grados, Felipe Lozano Castro, Yuri Alejandro Castro Rodríguez   +2 more
doaj  

First record of saw-belly (Hemiculter leucisculus Basilewsky, 1855) from Zarinehrud River, Urmia Lake basin and its some biological characteristics [PDF]

بوم‌شناسی آبزیان, 2015
This study aimed to the first report of Saw-belly, Hemiculter leucisculus from the Zarinehrud River and investigation of its morphometric and meristic characteristics, length-weight and length-length relationships.
Alireza Radkhah, Soheil Eagderi
doaj