Results 51 to 60 of about 485,312 (296)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Stride length–velocity relationship during running with body weight support

Journal of Sport and Health Science, 2015
Background: Lower body positive pressure (LBPP) treadmills can be used in rehabilitation programs and/or to supplement run mileage in healthy runners by reducing the effective body weight and impact associated with running.
John A. Mercer, Carmen Chona
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Morphometric Studies on Subadult Liza subviridis and Sillago sihama from Sonmiani Bay (Miani Hor), Balochistan, Pakistan

Journal of Bioresource Management, 2014
Length-weight relationship of Liza subviridis and Sillago sihama (Family: Mugilidae; Class: Pisces and Family: Sillaginidae; Class: Pisces) in subadults sampled from Somiani Bay Balochistan, Pakistan during 2002, 2003􀀃and 2006 was analyzed.
Muhammad A. Gondal , Naureen A. Qureshi , Noor U. Saher   +2 more
doaj   +1 more source

Length-weight relationships of Lake Kariba fishes [PDF]

Naga, 1992
The parameters a and b of the length-weight relationship of the form W = aL super(b) were computed for 40 species from tables/graphs presented in E. Balon's Fishes of Lake Kariba, Africa.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Growth of the silverside Atherinella brasiliensis in a subtropical estuary with some insights concerning the weight-length relationship

Anais da Academia Brasileira de Ciências
Specimens of Brazilian silverside (Atherinella brasiliensis, n=9672) with a length range of 1.5 to 14.2 cm were captured in the intertidal areas of the Estuarine Complex of Paranaguá, Brazil, between August 2010 and July 2011.
BARBARA M. DE CARVALHO, JOSÉ RICARDO S. BARRADAS, NELSON F. FONTOURA, HENRY L. SPACH   +3 more
doaj   +1 more source

ICHTHYOFAUNA OF THE LOWER PART OF BLIZNEC STREAM [PDF]

Croatian Journal of Fisheries, 2009
The fish were sampled in the lower parts of the Bliznec stream using an electroaggregate on two separate occasions in November 2008. A total of 50 fish were sampled.
Marina Piria, Daniel Matulić, Nikica Šprem, Martin Reljanović, Hrvoje Novosel, Samuel Buničić, Ivan Kranjec, Ana Drašković, Dean Duduković, Ivan Medvidović, Joško Režić   +10 more
doaj  

Length-Weight Relationships of Fishes from Gökova Bay, Turkey (Aegean Sea)

Turkish Journal of Zoology, 2009
Bu çalışmada, 2006 yılı avcılık sezonu boyunca Gökova Körfezi’nde yakalanan 17 balık türü için boy-ağırlık ilişkileri verilmiştir. Örnekler küçük ölçekli fanyalı ağlar ile paragat balıkçılığından elde edilmiştir. İlişkinin b değeri Sphyraena sphyraena için 2,086 (±0,152) ile Scomber japonicus için 3,499 (±0,058) arasında değişmektedir ve b’nin ortanca ...
Ceyhan T., Erdem M., Akyol O.
openaire   +4 more sources