Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Length–weight relationship of seven freshwater fish species from Turkish Thrace
Journal of Applied Ichthyology, 2019 The length‐weight relationships (LWRs) of Alburnus istanbulensis Battalgil, 1941, Barbus tauricus Kessler, 1877, Cobitis pontica Vasil'eva & Vasil'ev, 2006, Cobitis strumicae Karaman, 1955, Gobio bulgaricus Drensky, 1926, Phoxinus strandjae Drensky, 1926 and Squalius orpheus Kottelat & Economidis, 2006 were analysed.
Gülşah Saç +3 more
openaire +3 more sources
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Length – Weight Relationships of Anodontia edentula from Mangrove Habitats of Surigao City, Philippines [PDF]
, 2021 Louella Sajol-Degamon, Eve V. Fernandez-Gamalinda
openalex +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
MORPHOMETRICS OF JUVENILE WHITE SHRIMP IN SANTOS (SP, BRAZIL) - AN ATLANTIC STRESSED ESTUARY
Boletim do Instituto de Pesca, 2020 Shrimps are one of the world’s most valuable fishing resources, with the Penaeidae family having the greatest economic importance. In the southwest Atlantic the white shrimp Litopenaeus schmitti plays an important socioeconomic role for small-scale ...
Felippe Veneziani ABBATEPAULO +2 more
doaj +1 more source
Weight-length relationship and relative condition factor of Micropterus salmoides (Lacépède, 1802), Cyprinus carpio (Linneaus, 1758) and Oreochromis niloticus (Linnaeus, 1758) caught in the Al-Massira Dam Lake [PDF]
, 2021 Sara Ouahb +4 more
openalex +1 more source
Length weight relationships of Nigerian freshwater fishes [PDF]
Naga, 1996 Length-weight relationships of 73 fish populations, covering 20 families, 28 genera and 40 species inhabiting freshwater ecosystems in Nigeria, were estimated (73 cases) or assembled from the literature (20 cases), and tested for difference between ecosystem types, There were no significant differences in the exponent of these relationships between ...
openaire +2 more sources