Results 181 to 190 of about 172,662 (343)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

open access: yesAdvanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian   +5 more
wiley   +1 more source

TRIP13 promotes the expansion and immunosuppression of CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells by sustaining HAT1 stability. [PDF]

open access: yesCell Death Dis
He T   +13 more
europepmc   +1 more source

Lentivirus Production v1

open access: yes
This protocol is about the production of lentivirus.
openaire   +1 more source

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

open access: yesAdvanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han   +9 more
wiley   +1 more source

Trastornos cognitivos asociados al VIH

open access: yesCiencia & Futuro
La neuroinfección por el Virus de Inmunodeficiencia Humana (VIH) puede manifestarse de diversas formas, desde trastornos cognitivos leves hasta enfermedades neurológicas graves, como la encefalopatía por VIH y las infecciones oportunistas del sistema ...
Kevin F. Gervacio Flores   +2 more
doaj  

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

open access: yesAdvanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang   +4 more
wiley   +1 more source

ZKSCAN3 promotes ovarian cancer cell proliferation by increasing HSPB1 expression. [PDF]

open access: yesFront Mol Biosci
Ke Q   +6 more
europepmc   +1 more source

Preclinical efficacy of a modified gamma-globin lentivirus gene therapy in Berkeley sickle cell anemia mice and human xenograft models

open access: gold
Archana Shrestha   +8 more
openalex   +1 more source

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