Results 181 to 187 of about 154,885 (187)

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

<i>SAMHD1</i> knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types. [PDF]

Front Genet
Li H, Afroze M, Arora G, Federman S, Shevade K, Yang YA, Nguyen P, Esanov R, Przybyla L, Litterman A, Shafer S.   +10 more
europepmc   +1 more source

Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function. [PDF]

J Am Heart Assoc
Singh S, Bruder A, Costa RM, Alves JV, Bharathi S, Goetzman ES, Bruder-Nascimento T.   +6 more
europepmc   +1 more source

Negative Regulation of Cell Adhesion as a Driver of Brain Metastasis in NSCLC Patients with EGFR Amplification. [PDF]

Biol Proced Online
Yang H, Hu C, Zhou Y, Tong T, Qi L, Yuan W, Shan C, Hong W, Wen L, Zhou C, Lei M.   +10 more
europepmc   +1 more source

Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis. [PDF]

Life (Basel)
Michurina S, Beloglazova I, Agareva M, Alekseeva N, Parfyonova Y, Stafeev I.   +5 more
europepmc   +1 more source

Strategies for Altering Delivery Technologies to Optimize CAR Therapy. [PDF]

Int J Mol Sci
Cao L, Liu Y, Lin G.
europepmc   +1 more source

Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading. [PDF]

iScience
Tang W, Yin JB, Lin RG, Wu CY, Huang JL, Zhu JJ, Yang LF, Li GM, Cai DZ, Liu LL, Liu YL, Zhang HY.   +11 more
europepmc   +1 more source