Results 181 to 190 of about 122,780 (298)

Development of a sensitive assay for detection of replication-competent recombinant lentivirus in large-scale HIV-based vector preparations [PDF]

, 2003
Paul A. Escarpe, Nathalie Zayek, Peggy S. Chin, Flavia Borellini, Romain Zufferey, Gábor Veres, Véronique Kiermer   +6 more
openalex   +1 more source

Osteoblast‐CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age‐Related Bone Loss

Advanced Science, EarlyView.
In the osteoblastic niche, SIRT1 activates and recruits CD4+ CTLs by increasing DAAM2 expression via EZH2 deacetylation and boosting the secretion of key chemokines, such as CCL3, CCL5, and CXCL10. Then, CD4+ CTL directly eliminates senescent osteoblasts in an MHC‐II‐dependent way, thereby slowing down the process of bone ageing and effectively ...
Bin Yang, Guofu Zhang, Yizhou Zhu, Jingcheng Wang, Xinmin Feng, Wenyong Fei, Jihang Dai, Le Hu, Yi Zhang, Jun Cai, Binjia Ruan, Yue Jin, Fanhao Wei, Gang Lu, Dongan Wang, Jason Pui Yin Cheung, Graham Ka Hon Shea, Hao Chen, Kelvin Wai Kwok Yeung, Lei Wang, Yongxiang Wang   +20 more
wiley   +1 more source

TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway. [PDF]

J Inflamm Res
Xia L, Wang Z, Chen X.
europepmc   +1 more source

Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors [PDF]

, 2003
John P. O’Rourke, Hajime Hiraragi, Kathleen E. Urban, Manij Patel, John C. Olsen, Bruce A. Bunnell   +5 more
openalex   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Locus Control Region of the Human CD2 Gene in a Lentivirus Vector Confers Position-Independent Transgene Expression

, 2001
Claudia Kowolik, Jun Hu, Jiing‐Kuan Yee   +2 more
openalex   +1 more source

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source

EZH2 promotes endometriosis progression through estrogen receptor and TNFα expression. [PDF]

Front Endocrinol (Lausanne)
Liu X, Cheng L, Huang L, Li M, Shen Q, Li D, Dai K, Fu Y, Li M, Yao P, Zeng L.   +10 more
europepmc   +1 more source

Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome

Advanced Science, EarlyView.
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang, Xiangbing Wu, Wenming Li, Haifeng Zhang, Yijun Wang, Jing Xu, Wenhao Li, Yi Qin, Zebin Wu, Gaoran Ge, Shujun Lv, Lu Mao, Liangliang Wang, Dechun Geng   +13 more
wiley   +1 more source

MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia. [PDF]

Eur J Med Res
Liao X, Liu R, Zhou T, Zhao X, Xiong X, Zhang K, Zheng Z, Xia X, Tang C, Gong Y, Du Q, Huang L, Zhu D, Zhou W, Liu Y, Jin Z.   +15 more
europepmc   +1 more source