Results 301 to 310 of about 169,744 (339)

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Haemophilia and access to gene therapy. [PDF]

EBioMedicine
Mahlangu J.
europepmc   +1 more source

Long Non‐Coding RNA IGFRIL Couples with PTBP1 to Destabilize IGFBP3 mRNA to Promote the IGF1R‐AKT‐mTOR Axis and Hepatocellular Carcinoma

Advanced Science, EarlyView.
The limited understanding of IGFR pathway activation hinders its clinical application in HCC. Here, IGFRIL is identified as a novel non‐coding activator of the IGF1R, which recruits PTBP1 to destabilize IGFBP3 mRNA and activates IGF1R, and proposes IGFRIL as a novel actionable target for HCC patients.
Jing Zhang, Chengming Gao, Haibei Li, Yuying Chen, Liting Yang, Qian Jin, Lan Feng, Xia Wang, Xinyi Liu, Hongxia Chen, Rong Ye, Yuanchao Xue, Huiyun Wang, Musheng Zeng, Ming Yang, Huaiqiang Ju, Chengzhi Gao, Guangming Zhou, Qi Zhang, Qian Zhang, Geng Qin, Yuanfeng Li, Yahui Wang, Aiqing Yang, Anfeng Si, Qingfeng Song, Fuchu He, Pengbo Cao, Gangqiao Zhou   +28 more
wiley   +1 more source

Effect of the CSFV NS5A protein on key proteins in the MAPK and PI3K-mTOR signaling pathways in porcine macrophages. [PDF]

Front Microbiol
Wang Y, Zheng X, Yang Y, Zhao X, Li M, Huang J, Zhang Q, Qin X, Yu Y, Pan Q, Cao Z.   +10 more
europepmc   +1 more source

Cancer Cell‐Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA

Advanced Science, EarlyView.
Venous thromboembolism (VTE) is a major threat to cancer patients. Cancer‐derived large extracellular vesicles deliver CYBA (p22phox) to neutrophils, triggering reactive oxygen species (ROS) and citrullinated histone H3 (citH3) formation. This drives neutrophil extracellular traps formation (NETosis), elevating VTE risk.
Xiangji Li, Yingjiao Ju, Chenjie Xu, Shixiang Ma, Lan Sun, Qingdong Guo, Mingyuan Liu, Yibin Xie, Li Min   +8 more
wiley   +1 more source

Perinatal hypoxia-mediated neurodevelopment abnormalities in congenital heart disease mouse model. [PDF]

Mol Med
Chen R, Wang H, Zeng L, He J, Liu X, Ji X, Yao P, Gu S.   +7 more
europepmc   +1 more source

TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia. [PDF]

Cell Death Dis
Li J, Chen B, Huang Y, Liao X, You J, Chen Z, Ning S, Reda A, Zhao J, Ran B, Bai J, Zhu M, Wang Y, Chen H, Wei Q, Cao D, Liu L.   +16 more
europepmc   +1 more source

Muscle-specific miR-499-5p delivered by small extracellular vesicles impairs endothelial function and ischemic hindlimb recovery in diabetic mice. [PDF]

Cardiovasc Diabetol
Cheng Z, Truongcao MM, Mallaredy V, Cimini M, Thej C, Joladarashi D, Gonzalez C, Benedict C, Verma SK, Garikipati VNS, Kishore R.   +10 more
europepmc   +1 more source

Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis. [PDF]

Nat Commun
Zhao C, Kong K, Liu P, Chen X, Rong K, Zhang P, Wang L, Wang X.   +7 more
europepmc   +1 more source

Protocol for high-efficiency generation of iPSCs stably expressing Cas9-EGFP using the selection by essential gene exon knockin method. [PDF]

STAR Protoc
Zhang Y, Yang H, Yang Y, Lu Z, Cheng L, Tan H, Zhang JZ.   +6 more
europepmc   +1 more source