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STAB1 Promotes Acute Myeloid Leukemia Progression by Activating the IKK/NF-κB Pathway and Increasing M2 Macrophage Polarization. [PDF]

Cancer Sci
Yin J, Luo J, Wang L, Liu L, Liu L.
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Titration of Lentivirus Vectors

Cold Spring Harbor Protocols, 2018
The titer of a lentivirus vector is often expressed in transducing units per milliliter. This is a functional titer that reflects the lentivirus’ ability to transduce a particular cell line under specific conditions. Transduction of other cell lines is likely to be different and will require optimization.
Miguel Sena-Esteves, Guangping Gao
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Lentivirus Replication and Regulation

Annual Review of Genetics, 1999
▪ Abstract  Lentiviruses are associated with chronic diseases of the hematological and neurological systems in animals and man. In particular, human immunodeficiency virus type 1 (HIV-1) is the etiological agent of the global AIDS epidemic. The genomes of lentiviruses are complex, encoding a number of regulatory and accessory proteins not found in ...
Flossie Wong-Staal, Kelli L. Kuhen, Hengli Tang   +2 more
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Lentivirus Transgenesis

2010
Lentiviral transgenesis is a promising alternative to direct microinjection of DNA into pronuclei, which is by and large restricted to certain mouse strains. Lentiviruses are complex retroviruses that integrate their genome into the host chromosome.
Alexander Pfeifer, Tiongti Lim, Katrin Zimmermann   +2 more
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A minimal lentivirus Tat

Journal of Virology, 1991
Transcriptional regulatory mechanisms found in lentiviruses employ RNA enhancer elements called trans-activation responsive (TAR) elements. These nascent RNA stem-loops are cis-acting targets of virally encoded Tat effectors. Interactions between Tat and TAR increase the processivity of transcription complexes and lead to efficient copying of viral ...
R Carroll, B M Peterlin, David Derse, Magda Carvalho   +3 more
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Gene delivery by lentivirus vectors

Molecular Biotechnology, 2007
The capacity to efficiently transduce nondividing cells, shuttle large genetic payloads, and maintain stable long-term transgene expression are attributes that have brought lentiviral vectors to the forefront of gene delivery vehicles for research and therapeutic applications in a clinical setting.
Adam S. Cockrell, Tal Kafri
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Lentivirus Production and Purification

2016
Lentiviral (LV) vectors offer unique advantages over other gene delivery systems, namely the ability to integrate transgenes into the genome of both dividing and nondividing cells. Detailed herein is a simple protocol for the production LV vectors, describing the triple transfection of an LV transfer vector and LV helper plasmids into HEK-293 cells ...
Matthew J. Benskey, Fredric P. Manfredsson   +1 more
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Pathogenesis of lentivirus infections

Nature, 1986
Following infection of animals or humans, lentiviruses play a prolonged game of hide and seek with the host's immune system which results in a slowly developing multi-system disease. Emerging knowledge of the disease processes is of some relevance to acquired immune deficiency syndrome (AIDS), which is caused by a virus possessing many of the ...
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Lentivirus-Mediated Gene Expression

2007
Lentiviruses have the capacity to enter and integrate their genetic material into cells that are not dividing. This property is retained in vectors based on these agents. They can thus effect gene delivery to cells that are difficult to transduce such as cardiac myocytes in vitro and in vivo.
Jing Zhao, Andrew M. L. Lever
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