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Lentivirus-Mediated Antagomir Expression
2010MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation via hybridisation to mRNAs. miRNA function can be inhibited by the so-called "antagomirs" - anti-sense RNA oligonucleotides complementary to individual miRNAs.
Ewa Surdziel +2 more
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Transduction of Human T Cell Subsets with Lentivirus
2021Lentivirus-mediated gene transfer is an efficient method to introduce a variety of transgenes to human T cells. Here we describe a protocol to transduce human CD4+, CD8+, or CD4+ regulatory T cells. To illustrate the method, we use transduction with lentivirus encoding an HLA-A2-specific chimeric antigen receptor (CAR) and a transduction marker as an ...
Vivian C.W. Fung +2 more
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Role of Macrophages in Lentivirus Infections
1988Publisher Summary This chapter discusses the role of macrophages in lentivirus infections. Cells of the mononuclear phagocytic system are important hosts for the replication of lentiviruses. This host–virus relationship has been studied most extensively in lentivirus infection in ruminants in which the macrophage plays two roles: (1) as a host cell ...
M C Zink, O Narayan
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Lentivirus Vectors in β-Thalassemia
2012Patients with β-thalassemia major require lifelong transfusions and iron chelation, regardless of the type of causative mutations (e.g., β⁰, β(E)/β⁰). The only available curative therapy is allogeneic hematopoietic transplantation, although most patients do not have an HLA-matched, geno-identical donor, and those who do still risk graft-versus-host ...
Olivier Negre +6 more
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Microinjecting Lentivirus into Mouse Embryos
Cold Spring Harbor Protocols, 2018This protocol describes the injection of lentivirus into the perivitelline space of fertilized oocytes. Embryos usually survive lentiviral injection well because only the zona is pierced.
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SIVsmmPBj14: An Atypical Lentivirus
1994SIV-PBj14 is atypical for a lentivirus in that infection of pig-tailed macaques usually does not result in long-term progressive disease; however, this model may potentially provide valuable information about the pathogenesis of HIV and the development of AIDS. By capitalizing on some of the unique properties of the virus and the model system discussed
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Serological evidence of an Australian bovine lentivirus
Veterinary Microbiology, 1999Recombinant 26 kDa capsid (CA) proteins of bovine lentiviruses, bovine immunodeficiency virus (BIV) and Jembrana disease virus (JDV), were expressed in Escherichia coli and utilised as antigens for an enzyme-linked immunosorbent assay (ELISA) and a western immunoblot (WIB) procedure for the detection of antibody in dairy cattle in Western Australia.
Burkala, E.J. +3 more
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Animal lentivirus- and HIV1-induced cytopathicity
Research in Virology, 1994No abstract available.[...]
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Silencing and Variegation of Gammaretrovirus and Lentivirus Vectors
Human Gene Therapy, 2005Retrovirus vectors integrate into the genome, providing stable gene transfer, but integration contributes in part to transcriptional silencing that compromises long-term expression. In the case of gammaretrovirus vectors based on murine leukemia virus, many integration events are completely silenced in undifferentiated stem cells and in transgenic mice.
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Pathogenesis of lentivirus-induced arthritis
Rheumatology International, 1989While it has been known for some years that there is an association between lentiviruses and slowly progressive joint diseases in ruminants, the realization that the human immunodeficiency virus, the cause of AIDS, is a lentivirus has made this group of virus the focus of a considerable research effort.
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