Results 321 to 330 of about 199,900 (336)
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Lentivirus Vectors in β-Thalassemia
2012Patients with β-thalassemia major require lifelong transfusions and iron chelation, regardless of the type of causative mutations (e.g., β⁰, β(E)/β⁰). The only available curative therapy is allogeneic hematopoietic transplantation, although most patients do not have an HLA-matched, geno-identical donor, and those who do still risk graft-versus-host ...
Emmanuel, Payen +5 more
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Role of Macrophages in Lentivirus Infections
1988Publisher Summary This chapter discusses the role of macrophages in lentivirus infections. Cells of the mononuclear phagocytic system are important hosts for the replication of lentiviruses. This host–virus relationship has been studied most extensively in lentivirus infection in ruminants in which the macrophage plays two roles: (1) as a host cell ...
O, Narayan, M C, Zink
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Microinjecting Lentivirus into Mouse Embryos
Cold Spring Harbor Protocols, 2018This protocol describes the injection of lentivirus into the perivitelline space of fertilized oocytes. Embryos usually survive lentiviral injection well because only the zona is pierced.
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Lentivirus infection of macrophages.
Immunology series, 1994The ovine and caprine lentiviruses infect monocytes, and the viral DNA is integrated into the cellular DNA. The provirus remains silent until the monocyte matures into a macrophage. Intrinsic to this maturation is the induction of a class of immediate early genes in the monocyte that includes the transcription factors JUN and FOS.
J E, Clements +3 more
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Lentivirus vectors for gene therapy
Biochemical Society Transactions, 1999A M, Lever +6 more
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Lentivirus expression vectors.
2007Research Signpost Transworld Research Network, Kerala (India)
CONESE, MASSIMO +3 more
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