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Transmission of small ruminant lentiviruses
Veterinary Microbiology, 2004Small ruminant lentiviruses (SRLV) are classical slow retroviruses causing chronic inflammatory disease in a variety of target organs. The routes of transmission have been investigated and a large body of evidence has accumulated over many years.
Blacklaws, Barbara +6 more
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Update on Small Ruminant Lentiviruses
Veterinary Clinics of North America: Food Animal Practice, 2021Small ruminant lentiviruses (SLRVs) have been recognized throughout the world for decades. SLRVs are a heterogenous group of viruses that can infect sheep, goats, and wild ruminants. Evidence supports cross-species infection. These viruses cause lifelong infections where they target specific organs, which can result in production losses due to ...
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Nature Genetics, 2000
The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence efficiency of gene delivery.
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The advantage that vectors derived from the human immunodeficiency virus offer over other gene-delivery vehicles is their ability to transduce non-proliferative tissues. But a report by Park et al. suggests that HIV-based vectors are not able to infect all non-dividing cells and that host cell activation may influence efficiency of gene delivery.
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Blood, 2002
Lineage-specific and high-level expression of transgenes introduced into hematopoietic stem cells have been the holy grail of gene therapy for over a decade. Initial excitement and competitiveness to be first quickly faded into frustration and disappointment as 2 major hurdles were identified ...
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Lineage-specific and high-level expression of transgenes introduced into hematopoietic stem cells have been the holy grail of gene therapy for over a decade. Initial excitement and competitiveness to be first quickly faded into frustration and disappointment as 2 major hurdles were identified ...
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The Nef protein of primate lentiviruses
Reviews in Medical Virology, 1999The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may accelerate HIV progression and disease in humans.
V, Piguet, D, Trono
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Lentiviruses as gene delivery vectors
Current Opinion in Biotechnology, 1999Lentivirus vectors are already used as effective gene delivery tools in cells from liver, retina, skeletal muscle and the central nervous system. In the past year, new and exciting data from gene transfer experiments in human hematopoietic progenitor cells have been obtained. Furthermore, new generations of HIV-1 based lentivirus vectors as well as new
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Diagnostic tests for small ruminant lentiviruses
Veterinary Microbiology, 2005Maedi visna virus and caprine arthritis encephalitis virus are closely related retroviruses that cause chronic inflammatory disease in small ruminants. The infections are characterised by insidious onset and slow progression. Diagnosis of infection is usually by serological testing.
Andrés, Damián F. de +6 more
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HIV-Related Lentiviruses of Nonhuman Primates
AIDS Research and Human Retroviruses, 1989The purpose of this review is to summarize the current status of known natural infections with SIV, the pathogenic potential of SIV in natural and unnaturual hosts, the genetic diversity of SIV, and possible monkey origins for HIV. In addition, we discuss the importance of SIV for studying the pathogenesis of AIDS and strategies for therapeutic and ...
R C, Desrosiers, M D, Daniel, Y, Li
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Small Ruminant Lentiviruses and Caseous Lymphadenitis
Veterinary Clinics of North America: Food Animal PracticeOvine progressive pneumonia and caprine arthritis encephalitis together are referred to as small ruminant lentiviruses (SRLVs). Along with caseous lymphadenitis (CL), SRLV are 2 of the so-called "iceberg diseases" of sheep and goats. In the case of SRLV, healthy tissue can be replaced with unproductive lymphoid tissue causing loss of milk, poor growth ...
Holly J, Neaton, Cindy, Wolf
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1994
The bovine immunodeficiency virus (BIV) is a horizontally transmitted, nonon-cogenic, pathogenic retrovirus and member of the lentivirus genus (Fig. 1). It was discovered in the late 1960s during the intensive search for the cause of bovine leukemia/lymphosarcoma.
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The bovine immunodeficiency virus (BIV) is a horizontally transmitted, nonon-cogenic, pathogenic retrovirus and member of the lentivirus genus (Fig. 1). It was discovered in the late 1960s during the intensive search for the cause of bovine leukemia/lymphosarcoma.
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