Results 41 to 50 of about 90,193 (247)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
GNSS Radio Occultation in Advanced Numerical Weather Prediction Models
GEOmedia, 2019 GPS-Radio Occultation (GPS-RO), and generally, Global Navigation Satellite System Radio Occultation (GNSS-RO), is a technique that measures the refractivity of the Earth’s atmosphere as a Low Earth Orbit (LEO) satellite listens to the radio signal of a ...
Guillermo Bosch
doaj
Quantum Mechanics and an Ontology of Intersubjectivity: Perils and Promises
Open Theology, 2018 Contemporary theology has realized the importance of integrating what we know from the “new physics”-quantum mechanics and relativity theory-into the metaphysical and ontological categories used by theology to consider God, the world, and the God-world ...
Pugliese Marc A.
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Радіоелектронні і комп'ютерні системиThe subject matter of this article is the contemporary software solutions used for modeling and visualizing spacecraft missions, specifically during the stages of launch, flight, and landing.
Oleksii Vynokur +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
The indigenous crayfish Austropotamobius pallipes complex in a national park of Central Italy
Knowledge and Management of Aquatic Ecosystems, 2011 The indigenous crayfish Austropotamobius pallipes complex has been recently defined by IUCN as an endangered species but our knowledge about its status in Italy is still provisional.
Mazza G. +6 more
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FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee +7 more
wiley +1 more source