Results 31 to 40 of about 77,216 (233)

Human beta-defensin 3 is up-regulated in cutaneous leprosy type 1 reactions. [PDF]

, 2012
BACKGROUND: Leprosy, a chronic granulomatous disease affecting the skin and nerves, is caused by Mycobacterium leprae (M. leprae). The type of leprosy developed depends upon the host immune response.
Chrissy H Roberts, Walker Stephen L., Deanna A Hagge, Anna L Cogen, Diana N J Lockwood, Deanna A. Hagge, Stephen L. Walker, Anna L. Cogen, Kapil D. Neupane, Neupane, Kapil D, Diana N. J. Lockwood, Lockwood, Diana NJ, Neupane Kapil D., Khadge, Saraswoti, Walker, Stephen L, Kapil D Neupane, Hagge, Deanna A, Cogen Anna L., Saraswoti Khadge, Stephen L Walker, Roberts Chrissy H., Lockwood Diana N. J., Hagge Deanna A., Khadge Saraswoti, Roberts, Chrissy H, Cogen, Anna L, Chrissy H. Roberts   +26 more
core   +1 more source

Clustering of leprosy beyond the household level in a highly endemic setting on the Comoros, an observational study

BMC Infectious Diseases, 2019
Background The island of Anjouan (Comoros) is highly endemic for leprosy with an annual incidence of 5–10/10,000. In May/June, 2015 single-dose Rifampicin post-exposure prophylaxis (SDR-PEP) was administered to 269 close contacts of 70 leprosy-patients ...
Nimer Ortuno-Gutierrez, Abdallah Baco, Sofie Braet, Assoumani Younoussa, Aboubacar Mzembaba, Zahara Salim, Mohamed Amidy, Saverio Grillone, Bouke C. de Jong, Jan Hendrik Richardus, Epco Hasker   +10 more
doaj   +1 more source

Protocol, rationale and design of PEOPLE (Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar): a cluster randomized trial on effectiveness of different modalities of implementation of post-exposure prophylaxis of leprosy contacts

BMC Infectious Diseases, 2019
Background Leprosy is an ancient infectious disease with a global annual incidence that has plateaued above 200,000 new cases since over a decade. New strategies are required to overcome this stalemate.
Nimer Ortuno-Gutierrez, Assoumani Younoussa, Andriamira Randrianantoandro, Sofie Braet, Bertrand Cauchoix, Stéphanie Ramboarina, Abdallah Baco, Aboubacar Mzembaba, Zahara Salim, Mohamed Amidy, Saverio Grillone, Jan Hendrik Richardus, Bouke C. de Jong, Epco Hasker   +13 more
doaj   +1 more source

On the Origin of Leprosy [PDF]

Science, 2005
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae . This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics,
Monot, Marc, Honoré, Nadine, Garnier, Thierry, Araoz, Romulo, Coppée, Jean-Yves, Lacroix, Céline, Sow, Samba, Spencer, John S., Truman, Richard W., Williams, Diana L., Gelber, Robert, Virmond, Marcos, Flageul, Béatrice, Cho, Sang-Nae, Ji, Baohong, Paniz-Mondolfi, Alberto, Convit, Jacinto, Young, Saroj, Fine, Paul E., Rasolofo, Voahangy, Brennan, Patrick J., Cole, Stewart T   +21 more
openaire   +5 more sources

The spatial distribution of leprosy in four villages in Bangladesh: an observational study. [PDF]

, 2008
BACKGROUND: There is a higher case-detection rate for leprosy among spatially proximate contacts such as household members and neighbors. Spatial information regarding the clustering of leprosy can be used to improve intervention strategies.
Richardus JH, EAJ Fischer, Richardus, J.H., Oskam, L. (Linda), pahan, D., Fisher, E. (Eric), Pahan D, Chowdhury SK, D Pahan, Chowdhury, S. (Susmita), Fischer EAJ, SK Chowdhury, Oskam L, Pahan, D. (David), Oskam, L, Chowdhury, S.K., Pahan, D, Fischer, E.A.J., Oskam, L., Richardus, Jan hendrik; id_orcid, L Oskam, Richardus, J.H. (Jan Hendrik), JH Richardus, Chowdhury, SK, Fischer, EAJ   +24 more
core   +2 more sources

Human immunodeficiency virus and leprosy: an update.

, 2011
Coinfection with human immunodeficiency virus (HIV) has a major effect on the natural history of many infectious diseases, particularly mycobacterial diseases.
Lambert, Saba M, Saba M. Lambert, Diana N.J. Lockwood, Lockwood, Diana NJ   +3 more
core   +1 more source

A comparison of the quality of life between survivors of leprosy living in a leprosarium and those re-integrated in their communities in the southern region of Malawi [PDF]

, 2011
Includes bibliographical references.The aim of this research was to compare the quality of life being experienced by survivors of leprosy living in the remaining leprosarium and those reintegrated into their communities in the southern region of ...
Chinguo, Dorothy
core   +1 more source

Tracing leprosy trends in Pakistan: a two-decade analysis of geographic and demographic shifts (2001–2023)

BMC Global and Public Health
Background Leprosy, or Hansen’s disease, is caused by Mycobacterium leprae and can lead to severe disabilities, social marginalisation and reduced quality of life.
Anil Fastenau, Nena Sophie Van Heesewijk, Matthew Willis, Paul Saunderson, Fabian Schlumberger, Ali Murtaza, Muhammed Iqbal, Abdul Salam, Sophie CW. Unterkircher, Elias Treml, Nimer Ortuño-Gutiérrez, Thomas Hambridge   +11 more
doaj   +1 more source

Introducing leprosy post-exposure prophylaxis into the health systems of India, Nepal and Indonesia: a case study

BMC Health Services Research, 2017
Background Leprosy has a wide range of clinical and socio-economic consequences. India, Indonesia and Nepal contribute significantly to the global leprosy burden. After integration, the health systems are pivotal in leprosy service delivery.
A. Tiwari, L. Mieras, K. Dhakal, M. Arif, S. Dandel, J. H. Richardus, LPEP Study Group   +6 more
doaj   +1 more source

Protocol of a comparative multicentric non inferiority clinical trial of WHO MBMDT with a new monthly chemotherapy regimen containing rifampicin, moxifloxacin and clarithromycin (RMC) on multibacillary patients from India

Trials
Background Current WHO MBMDT regimen has largely been successful in treating leprosy patients since 1984, when it was implemented worldwide. According to clinical presentation, pauci and multibacillary leprosy, the regimen is also given for 6 or 12 ...
Joydeepa Darlong, Samrun Nessa, Itu Singh, Utpal Sengupta, Reeta Devi, Kartikeyan Govindasamy, Neeta Maximus, Vandana Elkana, Anamika Haldar, Ann Miriam Jose, Sylvia Jayakumar   +10 more
doaj   +1 more source