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Divergence of Leptin Receptor and Interleukin-6 Receptor Subunit b in Early Vertebrate Evolution and Physiological Insights from the Sea Lamprey. [PDF]
Mol Biol EvolGong N +7 more
europepmc +1 more source
Histidine‐Containing Dipeptides in Obesity and Cardiometabolic Health: A Systematic Scoping Review
Obesity Reviews, EarlyView.ABSTRACT Background Histidine‐containing dipeptides (HCDs) have been reported to have anti‐inflammatory and antidiabetic properties. Yet, no previous reviews have examined the impact of HCDs on Type 2 diabetes (T2D) risk factors (e.g., obesity) and progression (e.g., microvascular and macrovascular complications).
Saeede Saadati +10 more
wiley +1 more source
Complex Interplay Between Obesity and BRCA1/2‐Associated Breast Cancer: An Overview
Obesity Reviews, EarlyView.ABSTRACT The steadily increasing prevalence of obesity and its association with a growing number of malignancies, including breast cancer, has made this disease spectrum an urgent and critical public health priority, demanding immediate attention and comprehensive action.
Cinzia Giordano +9 more
wiley +1 more source
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The Lancet, 1998
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, leptin was first described as an adipocyte-derived signalling factor, which, after interaction with ...
J, Auwerx, B, Staels
openaire +4 more sources
Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scientifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, leptin was first described as an adipocyte-derived signalling factor, which, after interaction with ...
J, Auwerx, B, Staels
openaire +4 more sources
Dermatitis : contact, atopic, occupational, drug, 2011
Leptin belongs to the helical cytokine family and has structural similarity to interleukin (IL)-6, IL-12, IL-15, prolactin, and growth hormone. It is mainly secreted by adipocytes but (at lower levels) also by stomach, skeletal muscle, and placenta.
Balato N +4 more
openaire +6 more sources
Leptin belongs to the helical cytokine family and has structural similarity to interleukin (IL)-6, IL-12, IL-15, prolactin, and growth hormone. It is mainly secreted by adipocytes but (at lower levels) also by stomach, skeletal muscle, and placenta.
Balato N +4 more
openaire +6 more sources
Molecular Aspects of Medicine, 2012
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence basal ...
Procaccini C, Jirillo E, Matarese G
openaire +7 more sources
Leptin is an adipocyte-derived hormone/cytokine that links nutritional status with neuroendocrine and immune functions. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. Initially described as an antiobesity hormone, leptin has subsequently been shown also to influence basal ...
Procaccini C, Jirillo E, Matarese G
openaire +7 more sources
The Netherlands Journal of Medicine, 1996
A highly conserved protein called 'leptin' was recently discovered to play a role in regulation of the energy balance in humans and rodents. This 167-amino-acid-containing protein is only produced and secreted by mature adipocytes. Absence of the protein in mutant ob/ob mice and resistance to its effects in db/db mice lead to extreme obesity and type ...
A E, Meinders, A C, Toornvliet, H, Pijl
openaire +2 more sources
A highly conserved protein called 'leptin' was recently discovered to play a role in regulation of the energy balance in humans and rodents. This 167-amino-acid-containing protein is only produced and secreted by mature adipocytes. Absence of the protein in mutant ob/ob mice and resistance to its effects in db/db mice lead to extreme obesity and type ...
A E, Meinders, A C, Toornvliet, H, Pijl
openaire +2 more sources
Nutrition Reviews, 2002
it is certainly a major player. Priorexperience with hormonal signals such as insulin sug-gested that leptin would have pleiotropic actions invarious end organs and that its signals would be inte-grated into a complicated system of checks and balancesinvolving other hormones and neural pathways. Thesepredictions have turned out to be true,
Prentice, Andrew M. +3 more
openaire +4 more sources
it is certainly a major player. Priorexperience with hormonal signals such as insulin sug-gested that leptin would have pleiotropic actions invarious end organs and that its signals would be inte-grated into a complicated system of checks and balancesinvolving other hormones and neural pathways. Thesepredictions have turned out to be true,
Prentice, Andrew M. +3 more
openaire +4 more sources