Case Report: Hereditary transthyretin amyloidosis in a Chinese family with the transthyretin variant p.Y89H [PDF]
Frontiers in NeurologyBackgroundHereditary transthyretin amyloidosis (hATTR) is a rare, life-threatening multisystem disorder caused by pathogenic variants in the transthyretin (TTR) gene.
Fengzhu Zhao +8 more
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Case Report: Five-year follow-up of leptomeningeal transthyretin amyloidosis (Ala45Thr) with CNS involvement under tolcapone therapy [PDF]
Frontiers in MedicineBackgroundTransthyretin (TTR) p.Ala45Thr variant is pathogenic, typically associated with cardiomyopathy and peripheral neuropathy. Leptomeningeal and central nervous system (CNS) involvement is rare, and longitudinal treatment data remain limited ...
Nataša Giedraitienė +2 more
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Cerebral Amyloid Angiopathy-Related Inflammation Mimicking Leptomeningeal Metastasis After Resected Lung Adenocarcinoma: A Case Report Highlighting Dynamic Diagnostic Reassessment [PDF]
Current OncologyCerebral amyloid angiopathy-related inflammation (CAA-ri) is a rare inflammatory subtype of cerebral amyloid angiopathy that may present with leptomeningeal enhancement on magnetic resonance imaging (MRI), thereby mimicking leptomeningeal metastasis (LM)
Kodai Shigeyama +12 more
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Clinico-aetiological Profile of Meningoencephalitis: A Prospective Observational Study in a Tertiary Care Centre, Hubli, Karnataka, India [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Meningoencephalitis is a syndrome leading to fatality and neurological damages. Worldwide, infection of the central nervous system is the most common cause of meningoencephalitis.
Amruth +3 more
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Case report: Systemic T-DXd and bevacizumab plus local therapy prolongs survival in breast cancer leptomeningeal metastasis: a case series and literature review [PDF]
Frontiers in OncologyLeptomeningeal metastasis from breast cancer has a low incidence but an extremely poor prognosis. With the development of antitumor therapies, the survival of patients with metastatic breast cancer has been significantly prolonged.
Junmei Zhang +4 more
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Leptomeningeal carcinomatosis or ischemic cerebrovascular disease?
Clinical Case Reports, 2021 A lung cancer patient suspected to have leptomeningeal carcinomatosis was referred for radiation. A careful evaluation of the MRI by a neuroradiologist revealed multiple brain infarcts. Multidisciplinary meetings are important for patient's case.
Ayelet Eran, Orit Kaidar‐Person
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Immunotherapy in NSCLC Patients With Brain and Leptomeningeal Metastases
Frontiers in Oncology, 2022 Immunotherapy has now been integrated as a treatment strategy for most patients with non-small cell lung cancer (NSCLC). However, the pivotal clinical trials that demonstrated its impressive efficacy often did not include patients with active, untreated ...
Thomas Pierret +7 more
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Frontiers in Oncology, 2023 Network targeting of disease-specific nodes represents a useful principle for designing combination cancer therapy. In this case of a patient with relapsed leptomeningeal glioblastoma, comprehensive molecular diagnosis led to the identification of a ...
Michael P. Castro +5 more
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Frontiers in Immunology, 2023 BackgroundMyelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a newly defined autoimmune inflammatory demyelinating central nervous system (CNS) disease characterized by antibodies against MOG.
Li Li +8 more
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BMC Neurology, 2023 Background Spinal neuraxis leptomeningeal metastasis (LM) relapse in glioblastoma is an uncommon event that is challenging to manage. This study aims to determine the incidence, associated factors, and outcome of LM relapse in patients with glioblastoma ...
Eric Wegener +7 more
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