Advanced Science, EarlyView.Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng +12 more
wiley +1 more source
FoodsHousehold food waste represents a major environmental, economic and social challenge, particularly in developing countries where empirical evidence remains limited.
Ahmed Yangui +2 more
doaj +1 more source
Considerações ergonômicas sobre a atividade de trabalho de um cirugião dentista: um enfoque sobre as LER/DORT / [PDF]
, 2000 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.As Lesões por Esforços Repetitivos (LER) ou Distúrbios Osteomusculares Relacionados ao Trabalho (DORT), são enfermidades de caráter ocupacional, que comprometem ...
Ulbricht, Cláudia
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Atmospheric CO2 exchanges measured by eddy covariance over a temperate salt marsh and influence of environmental controlling factors [PDF]
BiogeosciencesWithin the coastal zone, salt marshes are atmospheric CO2 sinks and represent an essential component of biological carbon (C) stored on earth due to a strong primary production.
J. Mayen +14 more
doaj +1 more source
Ecological Indicators, 2023 Assessing the landscape ecological risk (LER) will facilitate optimal planning of land-use patterns and mitigating regional ecological risks, especially in megacities under rapid urbanization.
Bingjie Li +4 more
doaj +1 more source
Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy
Advanced Science, EarlyView.ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin +8 more
wiley +1 more source
Drivers of tail evolution in squamates and their implications for the fossorial origin of snakes
The Anatomical Record, EarlyView.Abstract The axial skeleton serves as the primary structural support in all vertebrates and is subdivided into five distinct regions: cervical, thoracic, lumbar, sacral, and caudal. Relaxation of constraints acting on the terminal end of the axial skeleton has led to remarkable variation in caudal vertebrae number across Squamata.
Olivia Binfield +2 more
wiley +1 more source
Ler é imprescindível: ler o quê? Ler como? [PDF]
, 2017 Este trabalho se ocupa da busca pelo entendimento das condições de leitura do povo brasileiro;traz dados estatísticos sobre leitura e analfabetismo (abrangendo dados do IBGE na última década), quemostram o panorama oficial e o não oficial, e faz ...
Siqueira, Sena
core +1 more source
Emendation of the genera Selenopemphix and Multispinula (Peridiniales, Dinophyceae), with the description of Multispinula varispinosa sp. nov. and Multispinula robusta sp. nov. [PDF]
Journal of MicropalaeontologyThe taxonomy of the dinoflagellate cyst-based genera Selenopemphix and Multispinula has long needed revision. This is accomplished here by a multiproxy approach combining incubation experiments and morphological and molecular (partial LSU rDNA) analyses ...
O. David +8 more
doaj +1 more source
A influência das características anatomo-físicas no aparecimento das lesões por esforços repetitivos em uma linha de produção [PDF]
, 2002 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção.O estudo teve como objetivo investigar a influência dos fatores individuais como as medidas dos segmentos corpóreos ...
Geremias, Jovenal João
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