Results 111 to 120 of about 21,570 (177)

From Thrombolysis to Transplant: Navigating the Storm of Delayed STEMI and Cardiogenic Shock

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Delayed STEMI presentation can cause extensive myocardial necrosis, left ventricular thrombus, cardiogenic shock, and progression to end‐stage heart failure despite reperfusion. Early recognition and timely transfer to specialized shock centers are critical.
Syed Rafay Hussain Zaidi, Muhammad Sheraz Hameed, Muhammad Ahsan, Hamza Ishfaq, Ali Iqbal, Azka Mirza, Sadia Rekhum, Muhammad Sohaib Alvi, Muhammad Usama Naveed   +8 more
wiley   +1 more source

The Critical Importance of Recognizing De Winter's T-wave Pattern: A Case of Acute Proximal LAD Occlusion by In-Stent Restenosis. [PDF]

Cureus
Chin-Yuan H, Keng-Yi W.
europepmc   +1 more source

Glymphatic System Dysfunction in Central Nervous System Diseases

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran, Omar Abu‐Khazneh, Mohammad Bdair, Orabi Hajjeh, Mohammed AbuBaha, Waseem Shehadeh, Ameer Awashra, Ibrahim Alazizi, Raya Fuqha, Sakeena Saife, Hasan Fuqha, Fathi Milhem, Husam Hamshary, Dana Abuzahra, Umar Shuaib   +14 more
wiley   +1 more source

Limitations and Blind Spots of Diffusion-Weighted Imaging in the Evaluation of Acute Brain Ischemia: A Narrative Review. [PDF]

J Clin Med
Nikolakakis I, Koutroulou I, Mantatzis M, Finitsis S, Grigoriadis N, Karapanayiotides T.   +5 more
europepmc   +1 more source

Restricting Synaptotagmin‐3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re‐Programming

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Restriction of Syt3 internalization by peptide 3Y conferred robust neuroprotection against cerebral ischemia/reperfusion injury. Mechanistically, 3Y suppressed neuronal apoptosis fundamentally, and additionally, these salvaged neurons orchestrated and remodulated the transformation of surrounding microglia toward an anti‐inflammatory and ...
Hua Xu, Hongbo Mi, Rong Cheng, Tiantian Gui, Fangzhou Hu, Yi Yang, Jian Cheng, Qun Xue   +7 more
wiley   +1 more source

Current perspective in acute ischemic stroke: net water uptake and imaging-guided selection as bridges to personalized, tissue-based care. [PDF]

Front Neurol
Broocks G, Werner R, Sentker T, Minnerup J, Kemmling A.   +4 more
europepmc   +1 more source

IL‐17A Promotes NETs Formation via the PKCζ–ERK–ROS–PAD4 Pathway in a Mouse Model of Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Our study demonstrates that IL‐17A promotes NET formation by upregulating PAD4 through the PKCζ–ERK–ROS pathway, thereby exacerbating ischemic brain injury. IL‐17A regulates NET formation through this newly identified molecular pathway, and targeting this pathway may offer a novel therapeutic strategy for stroke.
Chang Liu, Qi Chen, Weijia Chen, Xinyue Han, Xiaowen Qiao, Jun Guo, Wei Su, Qingqing Dai   +7 more
wiley   +1 more source

CO₂ inhalation enhances pericyte-mediated neurovascular protection in ischemic stroke and remains safe in hemorrhagic stroke. [PDF]

J Cereb Blood Flow Metab
Yoon CE, Jung JW, Kim YB, Song J, Joo H, Kim B, Kwon I, Yoon SS, Kim JS, Choi HY, Kim YD, Heo JH, Nam HS.   +12 more
europepmc   +1 more source

Macrophage‐derived galectin‐3 contributes to pyroptosis, apoptosis and necroptosis through TLR4/MyD88/NF‐κB/NLRP3 during atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Pyroptosis, apoptosis and necroptosis of macrophages occur concurrently during atherosclerosis. Galetein‐3 and NLRP3 are highly expressed in atherosclerotic lesions. Galectin‐3 is principally expressed in macrophages within atherosclerotic plaques. Galectin‐3 interacts with NLRP3, activates TLR4/MyD88/NF‐κB/NLRP3 signal axis, and promotes PANoptosis ...
Zihui Yuan, Haitao Li, Bing Xing Ruan, Hongyi Huang, Yiqing Li, Jian Wang   +5 more
wiley   +1 more source

Remote Ischemic Preconditioning Exerts Neuroprotective Effects Via the PGC-1α/FNDC5/BDNF Pathway in Focal Brain Ischemia of Rats. [PDF]

Transl Stroke Res
Matsuoka T, Matsuzaki R, Nakanishi K, Kakimoto S, Kato Y, Otsuka S, Kikuchi K, Sakakima H.   +7 more
europepmc   +1 more source