Results 11 to 20 of about 1,344,206 (319)

Pan-cancer patterns of cuproptosis markers reveal biologically and clinically relevant cancer subtypes

Biomarker Research, 2023
Cuproptosis is a newly discovered type of cell death triggered by copper accumulation. Here we exhibited the genetic profiles of 10 cuproptosis-associated genes (CuAGs) across 21 cancer types.
Fanqin Bu, Xiangji Li, Yu Zhao, Liyi Bai, Shutian Zhang, Li Min   +5 more
doaj   +1 more source

Hypersomnia associated with bilateral posterior hypothalamic lesion - A polysomnographic case study [PDF]

, 2003
We examined an obese 58-year-old patient with a bilateral posterior hypothalamic lesion of unknown etiology. A 24-hour polysomnography revealed a markedly increased total sleep time (17.6 h). During daytime, only 3 continuous wake phases occurred.
Uttner, I., Helmchen, C., Kleine, J., Eisensehr, Ilonka, Seelos, Klaus, Schlippenbach, C. von, Noachtar, S.   +6 more
core   +1 more source

Lesion size and long-term cognitive outcome after pediatric stroke: A comparison between two techniques to assess lesion size. [PDF]

, 2023
BACKGROUND There is little consensus on how lesion size impacts long-term cognitive outcome after pediatric arterial ischemic stroke (AIS). This study, therefore, compared two techniques to assessed lesion size in the chronic phase after AIS and ...
Everts, Regula, Bertato, Shana, Slavova, Nedelina, Grunt, Sebastian, Steiner, Leonie, Steinlin, Maja   +5 more
core   +1 more source

Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics

View, 2023
Extracellular vesicles (EVs) become one of the most important sources of cancer biomarkers during the past decade due to their wide distribution in body fluids and physiological stability.
Liyi Bai, Fanqin Bu, Xiangji Li, Shutian Zhang, Li Min   +4 more
doaj   +1 more source

Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke [PDF]

, 2009
<p><b>Background and Purpose:</b> Clinical research into the treatment of acute stroke is complicated, is costly, and has often been unsuccessful.
Bolland, Kim, Lees, Kennedy J., Lihic, A., Bolland, K., Lihic, A., Lees, Kennedy, Ali, M., Lihic, Anela, Lees, K.R., Valdes-Marquez, E., Bolland, K., Whitehead, J., Ali, Myzoon, Valdes-Marquez, E., Whitehead, J., Ali, M., Whitehead, John, Lees, K., Valdés-Márquez, Elsa   +18 more
core   +1 more source

Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

BMC Medicine, 2022
Background The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood.
Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu   +6 more
doaj   +1 more source

Brain lesion volume and capacity for consent in stroke trials: potential regulatory barriers to the use of surrogate markers [PDF]

, 2008
<p><b>Background and Purpose:</b> European directives and legislation in some countries forbid inclusion of subjects incapable of consent in research if recruitment of patients capable of consent will yield similar results.
Muir, K.W., Dani, K.A., McCormick, M.T.
core   +1 more source

Lesion Preparation with Orbital Atherectomy [PDF]

, 2019
Despite significant improvements in stent design, severe coronary calcification continues to impede adequate stent expansion and is associated with worse clinical outcomes.
Ziad A Ali, Allen Jeremias, Evan Shlofmitz, Richard Shlofmitz   +3 more
core   +1 more source

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Cancer Cell International, 2019
Background 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro ...
Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang   +3 more
doaj   +1 more source

Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats [PDF]

, 2008
<p><b>Background and Purpose:</b> The study aim was to assess the effects of magnesium sulfate (MgSO4) administration on white matter damage in vivo in spontaneously hypertensive rats.</p> <p><b>Methods:</b> ...
McCabe, C., Lees, K.R., Muir, K., Lecrux, C., Weir, C.J., Mullin, J., Touzani, O., Macrae, I.M., Gallagher, L.   +8 more
core   +1 more source