Results 21 to 30 of about 1,170,373 (268)

Mass spectrometry‐based extracellular vesicle micromolecule detection in cancer biomarker discovery: An overview of metabolomics and lipidomics

View, 2023
Extracellular vesicles (EVs) become one of the most important sources of cancer biomarkers during the past decade due to their wide distribution in body fluids and physiological stability.
Liyi Bai, Fanqin Bu, Xiangji Li, Shutian Zhang, Li Min   +4 more
doaj   +1 more source

Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study

BMC Medicine, 2022
Background The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood.
Shanshan Wu, Changzheng Yuan, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu   +6 more
doaj   +1 more source

Pan-cancer patterns of cuproptosis markers reveal biologically and clinically relevant cancer subtypes

Biomarker Research, 2023
Cuproptosis is a newly discovered type of cell death triggered by copper accumulation. Here we exhibited the genetic profiles of 10 cuproptosis-associated genes (CuAGs) across 21 cancer types.
Fanqin Bu, Xiangji Li, Yu Zhao, Liyi Bai, Shutian Zhang, Li Min   +5 more
doaj   +1 more source

Large tumor suppressor kinase 2 overexpression attenuates 5-FU-resistance in colorectal cancer via activating the JNK-MIEF1-mitochondrial division pathway

Cancer Cell International, 2019
Background 5-Fluorouracil (5-FU) is a standard treatment for colorectal cancer, but most patients develop 5-FU resistance. Here, we conducted experiments to identify an effective approach to augment 5-FU-based treatment in colorectal cancer in vitro ...
Weilong Yao, Shengtao Zhu, Peng Li, Shutian Zhang   +3 more
doaj   +1 more source

Evaluation of circulating small extracellular vesicles derived miRNAs as biomarkers of early colon cancer: a comparison with plasma total miRNAs

Journal of Extracellular Vesicles, 2019
Early diagnosis of colon cancer (CC) is clinically important, as it can significantly improve patients’ survival rate and quality of life. Although the potential role for small extracellular vesicles (sEVs) in early detection of many diseases has been ...
Li Min, Shengtao Zhu, Lei Chen, Xiang Liu, Rui Wei, Libo Zhao, Yuqing Yang, Zheng Zhang, Guanyi Kong, Peng Li, Shutian Zhang   +10 more
doaj   +1 more source

MGP Promotes Colon Cancer Proliferation by Activating the NF-κB Pathway through Upregulation of the Calcium Signaling Pathway

Molecular Therapy: Oncolytics, 2020
Matrix Gla protein (MGP), an extracellular matrix protein, is mainly associated with the inhibition of calcification in skeleton, coronary artery, and kidney, and more recently it has also been implicated in cancer.
Xueqing Li, Rui Wei, Mizhu Wang, Li Ma, Zheng Zhang, Lei Chen, Qingdong Guo, Shuilong Guo, Shengtao Zhu, Shutian Zhang, Li Min   +10 more
doaj   +1 more source

Integrated Analysis Identifies Molecular Signatures and Specific Prognostic Factors for Different Gastric Cancer Subtypes

Translational Oncology, 2017
BACKGROUND: Gastric cancer (GC) is the fifth leading cause of cancer-related deaths worldwide. As an effective and easily performed method, microscopy-based Lauren classification has been widely accepted by gastrointestinal surgeons and pathologists for ...
Li Min, Yu Zhao, Shengtao Zhu, Xintao Qiu, Rui Cheng, Jie Xing, Linlin Shao, Shuilong Guo, Shutian Zhang   +8 more
doaj   +1 more source

Prognostic significance of KLF4 in solid tumours: an updated meta-analysis

BMC Cancer, 2022
Background Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues.
Xiaoya Luo, Yue Zhang, Ying Meng, Ming Ji, Yongjun Wang   +4 more
doaj   +1 more source

Intracellular matrix Gla protein promotes tumor progression by activating JAK2/STAT5 signaling in gastric cancer

Molecular Oncology, 2020
Matrix Gla protein (MGP) has been widely reported as an extracellular matrix protein with abnormal expression in various types of cancer. However, the function of intracellular MGP in gastric cancer (GC) cells remains largely unknown.
Mizhu Wang, Lei Chen, Yu Chen, Rui Wei, Qingdong Guo, Shengquan Zhu, Shuilong Guo, Shengtao Zhu, Shutian Zhang, Li Min   +9 more
doaj   +1 more source

Non-Thermal Plasma Jet-Treated Medium Induces Selective Cytotoxicity against Mycobacterium tuberculosis-Infected Macrophages

Biomedicines, 2022
Plasma-treated media (PTM) serve as an adjuvant therapy to postoperatively remove residual cancerous lesions. We speculated that PTM could selectively kill cells infected with Mycobacterium tuberculosis (Mtb) and remove postoperative residual tuberculous
Chae Bok Lee, Kang In Lee, Young Jae Kim, In Taek Jang, Sintayehu Kebede Gurmessa, Eun Ha Choi, Nagendra Kumar Kaushik, Hwa-Jung Kim   +7 more
doaj   +1 more source