Results 41 to 50 of about 1,346 (286)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Incidencia y evolución de lesiones epiteliales cervicouterinas en mujeres menores de 25 años

Revista de Ciencias Médicas de Pinar del Río, 2018
Introducción: las mujeres menores de 25 años constituyen un grupo de riesgo para las lesiones cervicales uterinas y hay que conocer la incidencia, la tendencia temporal y la evolución histológica de las mismas.
Raydel Marrero Fernández, José Guillermo Sanabria Negrín, Ana Margarita Barrabés Mazón, Inalvis de la Caridad Cruz Hernández   +3 more
doaj  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Prevalencia de lesiones intraepiteliales cervicales en el Hospital de Ventanilla – Callao 2016 [PDF]

, 2017
Determina la prevalencia de lesiones intraepiteliales cervicales en el Hospital de Ventanilla del Callao, 2016, para lo cual identifica las características generales de las mujeres jóvenes y adultas en el que prevalecen las lesiones, identifica la ...
Fabián Gómez, Ysabel Elvira
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Lesiones cervicales no cariosas en pacientes adultos. Revisión de la literatura.

, 2022
Introducción: La lesión cervical no cariosa, se ha definido como la pérdida de estructura dental en la unión cemento-esmalte que no está relacionada con la caries dental; el esmalte se afina progresivamente aproximándose a la unión cemento-esmalte, por ...
Riera Arteaga, Christina Valeria
core  

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Lesiones cervicales no cariosas en pacientes del área de salud "Eléctrico", municipio Arroyo Naranjo, 2015

Revista Cubana de Estomatología, 2017
Introducción: las lesiones cervicales no cariosas son la pérdida patológica de la estructura dentaria localizada en el límite amelo-cementario, que no responden a un agente causal bacteriano. Teniendo en cuenta la incidencia de esta afección en la salud
Hilda Elia Rodriguez Chala, Yaima Hernández Pampim, Ciro Gonzáles Fernández   +2 more
doaj  

Prevalencia y Factores de Riesgo de las Lesiones Cervicales No Cariosas en la dentición permanente 2015 [PDF]

, 2016
Resumen: El propósito de este estudio fue determinar la prevalencia y factores de riesgo de las lesiones cervicales no cariosas en estudiantes de odontología de la Universidad Católica de Santiago de Guayaquil-Ecuador.
Gallardo Bastidas Juan Carlos
core