Results 121 to 130 of about 2,808,044 (312)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
AN OUTBREAK OF FOOT AND MOUTH DISEASE IN A HERD OF CROSSBRED CATTLE
Pakistan Veterinary Journal, 2002 During the months of December 200 I and January 2002, an outbreak of Foot and Mouth disease (Foot and Mouth Disease type-A virus) was recorded in a crossbred dairy herd at Livestock Experiment Station, Qadirabad.
Rashid Ahmad, Javaid Iqbal and Ghu1am Akbar1
doaj
Foot-pad dermatitis in broilers and turkeys [PDF]
, 1998 Foot-pad dermatitis is a condition characterised by lesions on the ventral foot-pads of poultry. It is a type of contact dermatitis, which in an early stage results in hyperkeratosis, erosions and discoloration of the skin.
Berg, Charlotte C.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Conservative management of large post-intubation tracheal laceration
Annals of Cardiac AnaesthesiaTracheal rupture is a very rare but life-threatening complication of endotracheal intubation. It is more common in women and patients older than 50 years old.
Athanasia Vlahou +3 more
doaj +1 more source
Cystic Lesions of the Pancreas [PDF]
, 2014 With the increasing use of abdominal imaging, cystic lesions of the pancreas are being more frequently detected. These lesions may carry a significant premalignant potential.
Azzopardi, Neville
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source