Results 231 to 240 of about 487,432 (309)

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Chemical composition and larvicidal efficacy of essential oils from three artemisia species endemic to the Mediterranean region against <i>Culex pipiens</i> (L.), insecticide-resistant vector: <i>in vivo</i> and <i>in silico</i> studies. [PDF]

Front Plant Sci
Chebbac K, Guerguer F, Chalkha M, El Moussaoui A, Bassouya M, Lafraxo S, Saleh N, Benziane Ouaritini Z, Chtita S, Guemmouh R.   +9 more
europepmc   +1 more source

Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis

Advanced Science, EarlyView.
Considering the great challenge in Glioblastoma multiforme (GBM) treatment, the authors designed and synthesized a multifunctional nanoplatform that effectively induced ferroptosis by synergetically inhibiting intrinsic intrisinc anti‐ferroptosis proteins, GPX4 & DHODH, and realized excellent in vitro and in vivo anti‐GBM effect.
Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang   +12 more
wiley   +1 more source

Transfer of anti-Klebsiella pneumoniae immunity following infection in mice is protective against lethal challenge in offspring. [PDF]

Sci Rep
Mason E, Winter K, Liang J, Hakimpour S, Patel R, Harn T, Chu KH, Shulha H, Cai B, Lo M, Sadarangani M.   +10 more
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

A dynamic pharmacometric framework defining the relationship between ivermectin exposure and mosquito lethality

Hoglund RM, Kobylinski KC, Jittamala P, Hanboonkunupakarn B, Wamaket N, Sriwichai P, Phasomkusolsil S, White NJ, Day NP, Tarning J.   +9 more
europepmc   +1 more source

Optimizing endectocide and ectocide compound evaluation in Anopheles malaria vectors. [PDF]

Parasit Vectors
Kobylinski KC, Hongsuwong T, Khemrattrakool P, Kaewkhao N, Kullasakboonsri R, Phanphoowong T, Sriwichai P, Hanboonkunupakarn B, Jittamala P, Tarning J.   +9 more
europepmc   +1 more source

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Repellent, Lethal Activity, and Synergism of <i>Cannabis sativa</i> Extracts with Terpenes Against a Laboratory Colony of <i>Triatoma infestans</i>. [PDF]

Plants (Basel)
Dadé MM, Daniele MR, Rodriguez S, Díaz P, Silvestrini MP, Schinella GR, Marin GH, Barrio D, Prieto Garcia JM.   +8 more
europepmc   +1 more source