Results 31 to 40 of about 487,432 (309)

Design, synthesis, in vitro inhibition and toxicological evaluation of human carbonic anhydrases I, II and IX inhibitors in 5-nitroimidazole series

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
With the aim to obtain novel compounds possessing both strong affinity against human carbonic anhydrases and low toxicity, we synthesised novel thiourea and sulphonamide derivatives 3, 4 and 10, and studied their in vitro inhibitory properties against ...
Ashok Aspatwar   +8 more
doaj   +1 more source

Comparative Analysis between Ecotoxicity of Nitrogen-, Phosphorus-, and Potassium-Based Fertilizers and Their Active Ingredients

open access: yesToxics, 2016
This study aimed to analyze the ecotoxicity of nitrogen-, phosphorus-, and potassium-based compounds to organisms of two different trophic levels in order to compare the toxic effect between high-purity substances and these substances as components of ...
Nathan de Castro Soares Simplício   +6 more
doaj   +1 more source

Vancomycin minimum inhibitory concentrations and lethality in Staphylococcus aureus bacteremia [PDF]

open access: yesGERMS, 2015
After the dissemination of penicillin and oxacillin resistance in Staphylococcus aureus, vancomycin-intermediate and vancomycin resistant isolates have been reported. Even between isolates with minimum inhibitory concentrations (MICs) within the susceptible range, some authors have demonstrated that higher MICs correlate with higher lethality.To test ...
Felipe, Sulla   +5 more
openaire   +2 more sources

Toxicity of Bacillus thuringiensis at different larval ages of Agrotis ipsilon (Lepidoptera: Noctuidae)

open access: yesRevista de Ciências Agroveterinárias, 2020
The black cutworm Agrotis ipsilon (Hufnagel) (Lepidoptera: Noctuidae) is a cosmopolitan and polyphagous pest that attacks diverse crops and weed. One of the alternatives to insecticides may be the use of bioinsecticides based on Bacillus thuringiensis ...
Ingrid Schimidt Kaiser   +4 more
doaj   +1 more source

Evaluation of resistance and susceptibility level of single and double gene Bt cotton against Armyworm and American bollworm

open access: yesInternational Journal of Applied and Experimental Biology
Bt cotton was developed against lepidopteran insects and got a significant attraction by the Pakistani farmers to control target pests. The experiment was conducted to determine the resistance and susceptibility level of lepidopteran insects against ...
Muhammad Amjad   +6 more
doaj   +1 more source

Lethal concentration of Golden Sea Cucumber killed Vibrio cholerae

open access: yesBali Medical Journal, 2021
Introduction: Diarrhea is still a considerable health problem today, especially in developing countries, including Indonesia. One common etiology of diarrhea is Vibrio cholerae, which still causes many problems, such as inappropriate use of antibiotics causes antibiotic resistance.
Herin Setianingsih   +3 more
openaire   +1 more source

Risks for public health related to the presence of tetrodotoxin (TTX) and TTX analogues in marine bivalves and gastropods [PDF]

open access: yes, 2017
Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

The ecological impact of different mechanisms of chronic sub-lethal toxicity on feeding and respiratory physiology [PDF]

open access: yes, 1994
Sub-lethal toxicity tests, such as the scope-for-growth test, reveal simple relationships between measures of contaminant concentration and effect on respiratory and feeding physiology.
Willows, R.
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

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