Results 81 to 90 of about 487,432 (309)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

IMPACT OF SOME CHITIN SYNTHESIS INHIBITORS ON THE FALL ARMYWORM, Spodoptera frugiperda (LEPIDOPTERA: NOCTUIDAE) [PDF]

Mesopotamia Journal of Agriculture
Maize, Zea mays L. is an economic cereal in Egypt. Numerous pests infested maize, but only a few of them caused high crop losses, such as FAW, Spodoptera frugiperda.
Gamal Hassan, Magda El-Damer, Mohamed Abolfadel   +2 more
doaj   +1 more source

lowest lethal concentration found

, 2019
Citation: 'lowest lethal concentration found' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.L03632 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Haematological Response of Clarias Gariepinus to Rubber Processing Effluent [PDF]

, 2013
Industrialization has led to huge waste generation over the last decades, the absence of adequate facilities for treating such wastes in most developing nations has led to the discharge of effluents into the environment without proper treatment ...
Dahunsi, S. O., Oranusi, S. U.
core  

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment [PDF]

, 2014
There is an urgent need for rapid methods to develop vaccines in response to emerging viral pathogens. Whole inactivated virus (WIV) vaccines represent an ideal strategy for this purpose; however, a universal method for producing safe and immunogenic ...
Achilefu, Samuel, Chen, Alexander, Donthi, Nisha, Hsieh, Wen-Han, Hung, Chien-Fu, Knoff, Jayne, La, Victor, Li, Yen-Der, Tsen, Kong-Thon, Tsen, Shaw-Wei David, Wu, Tzyy-Choou   +10 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Assessment of degree of risk from sources of microbial contamination in cleanrooms; 2: surfaces and liquids [PDF]

, 2015
The degree of risk from microbial contamination of manufactured products in healthcare cleanrooms has been assessed in a series of three articles. The first article discussed airborne sources, and this second article considers surface contact and ...
Eaton, T., Whyte, W.
core  

The effects of changing climate on faunal depth distributions determine winners and losers

, 2014
Changing climate is predicted to impact all depths of the global oceans, yet projections of range shifts in marine faunal distributions in response to changing climate seldom evaluate potential shifts in depth distribution.
Airriess, Anttila, Barve, Bijima, Bograd, Brewer, Brown, Brown, Burrows, Burrows, Campenot, Cheung, Clark, Collins, Cottin, Dulvy, Frederich, George, Gibbs, Hönisch, Jackson, Keeling, Kroeker, Li, Lodish, Matear, McClain, Menzies, Mestre, Mickel, Mickel, Munday, Nye, Oliphant, Perry, Pinksy, Poloczanska, Pörtner, Pörtner, Pörtner, Pörtner, Schmittner, Shaffer, Smith, Soberón, Somero, Somero, Stillman, Storch, Stramma, Sunday, Thatje, Thatje, Tillman, Vaquer-Sunyer, Walther, Warrant, Whitney, Williams, Yasuhara   +59 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source