Results 151 to 160 of about 17,950,531 (342)

Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release

Advanced Materials, EarlyView.
A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni, Nitzan Letko Khait, Adam Forman, Edward A. Armstrong, Karim Fouad, Molly S. Shoichet   +5 more
wiley   +1 more source

Cell Adhesion by Design: Engineering Tissue Culture Scaffolds With Adhesion Cues

Advanced Materials Interfaces, EarlyView.
ABSTRACT In scaffold‐based tissue engineering, the matrix should provide adequate adhesion cues for cell attachment, spreading, and function. Given the multitude of adhesion receptors and the diversity of scaffolds, there are many approaches to render scaffolds adhesive, even though they are not all equivalent.
Dalia Dranseike, Dhananjay V. Deshmukh, Mark W. Tibbitt, Céline Labouesse   +3 more
wiley   +1 more source

Çinko (Zn) ve bakırın (Cu) lethal ve sub-lethal konsantrasyonlarına maruz bırakılan kadife balıklarında (Tinca tinca L., 1758) bazı kan parametrelerinin incelenmesi

, 2011
Bu çalışmada esasiyel metaller olarak bilinen çinko (Zn) ve bakırın (Cu) Kadife balıkları (Tinca tinca L., 1758) için 96 saatlik LC50 değerlerinin belirlenmesi ve bu metallerin sub-lethal ve lethal konsantrasyonlarına maruz bırakılan balıklarda ...
Ergönül, Mehmet Borga
core  

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Synthetic lethal hubs associated with vincristine resistant neuroblastoma.

, 2011
Chemotherapy of cancer experiences a number of shortcomings including development of drug resistance. This fact also holds true for neuroblastoma utilizing chemotherapeutics as vincristine.
Cinatl, Jindrich, Michaelis, Martin, Fechete, Raul, Martin Michaelis, Jindrich Cinatl Jr., Barth, Susanne, Munteanu, Andreea, Bernd Mayer, Paul Perco, Olender, Tsviya, Raul Fechete, Mayer, Bernd, Doron Lancet, Inger, Aron, Lancet, Doron, Andreea Munteanu, Andreas Bernthaler, Arno Lukas, Tsviya Olender, Perco, Paul, Susanne Barth, Lukas, Arno, Aron Inger, Bernthaler, Andreas   +23 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Species-specific effects of mycorrhizal symbiosis on Populus trichocarpa after a lethal dose of copper

Ecotoxicology and Environmental Safety
Poplars have been identified as heavy metals hyperaccumulators and can be used for phytoremediation. We have previously established that their symbiosis with arbuscular mycorrhizal fungi (AMF) may alter their uptake, tolerance and distribution to excess ...
Amin Soltangheisi, Aysha Hales-Henao, Rodica Pena, Mark Tibbett   +3 more
doaj   +1 more source

Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity

Advanced Science, EarlyView.
This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley   +1 more source

Security in smart cities using YOLOv8 to detect lethal weapons

The increase in the illegal use of lethal weapons at a global level has reachedworrying figures, resulting in an increase in assaults and armed robberies.
Castillo-Turpo, Aron, Paiva-Peredo, Ernesto, Rodriguez-Rosas, Ederson, Acuna-Condori, Kevin   +3 more
core   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source