Results 131 to 140 of about 17,950,531 (342)
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
“This didn’t have to happen : lethal school violence as a modern social problem
, 2009 Although there are claims that lethal school violence represents a moral panic, it indeed is a modern social problem – but not an issue that is merely modern in nature. Studies on cases of lethal school violence previously focused on cases at the primary
Gallagher, Alexandra T
core
Effectiveness of non-lethal capabilities in a maritime environment [PDF]
, 2006 The attack on the USS Cole within a civilian port, and the increased threat of pirating and terrorism on the high seas, underscore the immediate need for a maritime non-lethal capability.
Sickinger, Lisa R.
core
Organizational-Level Police Discretion
, 2011 Research on police behavior suggests that discretion is vital to police decision making. Although discretion can originate from many sources (e.g., officers, situations, structure), relatively few studies examine how organizational variables affect ...
Jeffrey S. Nowacki
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Immune Checkpoint Inhibitor–Related Myositis and Associated Triad Overlap Syndrome
Arthritis Care &Research, EarlyView.Objective Immune checkpoint inhibitor (ICI) myositis is a rare but a highly morbid condition, particularly with the ICI myositis triad syndrome of myositis, myocarditis, and myasthenia gravis. We report the clinical characteristics of ICI myositis and all‐cause mortality in these patients.
Selene Rubino +9 more
wiley +1 more source
Arthritis Care &Research, Accepted Article.Objective JAK inhibitors (JAKis) have shown promising effects in early‐phase studies of SSc. We aimed to assess the safety and explore effectiveness of JAKis compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the EUSTAR cohort was performed.
Stefano Di Donato +27 more
wiley +1 more source
, 2013 Rana grylio virus (RGV) is a pathogenic iridovirus that has resulted in high mortality in cultured frog. Here, a recombinant RGV (i53R-RGV-lacIO) containing the inducible lac repressor! operator system was constructed.
Zhang, QY (reprint author), Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China. +4 more
core +1 more source
Advanced Functional Materials, EarlyView.We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li +6 more
wiley +1 more source
Acute and chronic lethality of Total Dissolved Gas supersatuated water on Leptobotia Elongata
工程科学与技术, 2017 :When high dams discharge high velocity flows, large amount of air was taken into the water downstream of the dams, and the intense aeration between water and air leads to the generation of total dissolved gas (TDG) supersaturation. It gives threatens to
yuanyuan +4 more
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