Results 31 to 40 of about 17,950,531 (342)

β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells

Journal of Infectious Diseases, 2021
Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral replication.
Shuntai Zhou, Collin S. Hill, Sanjay Sarkar, Longping V. Tse, Blaide M D Woodburn, R. Schinazi, T. Sheahan, R. Baric, M. Heise, R. Swanstrom   +9 more
semanticscholar   +1 more source

Prostate-Specific Antigen Levels as a Predictor of Lethal Prostate Cancer [PDF]

JNCI Journal of the National Cancer Institute, 2007
Rates of long-term survival among patients with untreated localized prostate cancer are high. To avoid unnecessary treatment, tools are needed to identify the small proportion of patients who are destined to develop lethal prostate cancer.To evaluate the accuracy of early changes in prostate-specific antigen (PSA) levels as predictors of prostate ...
Fall, Katja, Garmo, Hans, Andren, Ove, Bill-Axelson, Anna, Adolfsson, Jan, Adami, Hans-Olov, Johansson, Jan-Erik, Holmberg, Lars   +7 more
openaire   +4 more sources

CD4+ICOS+Foxp3+: a sub-population of regulatory T cells contribute to malaria pathogenesis

Malaria Journal, 2022
Background Regulatory T cells are known to play a key role to counter balance the protective immune response and immune mediated pathology. However, the role of naturally occurring regulatory cells CD4+CD25+Foxp3 + in malaria infection during the disease
Rubika Chauhan, Vikky Awasthi, Reva Sharan Thakur, Veena Pande, Debprasad Chattopadhyay, Jyoti Das   +5 more
doaj   +1 more source

Pulsed electric field treatment for the stimulation of microorganisms: Applications in food production

Research in Agricultural Engineering, 2022
The pulsed electric field (PEF) technology is a non-thermal processing technique usually used for microbial inactivation in food industries. The application of this technology at sub-lethal levels prior to or during the fermentation processes enhances ...
Sally El Kantar, Mohamed Koubaa
doaj   +1 more source

Viability of Pentadesma in reduced habitat ecosystems within two climatic regions with fruit harvesting

Journal of Biological Dynamics, 2022
Habitat loss and harvesting of non-timber forest products (NTFPs) significantly affect the population dynamics. In this paper, we propose a general mathematical modelling approach incorporating the impact of habitat size reduction and non-lethal ...
Maria C. A. Leite, Benito Chen-Charpentier, Folashade B. Agusto, Orou G. Gaoue, Natali Hritonenko   +4 more
doaj   +1 more source

Gut Microbiome-Dependent Metabolic Pathways and Risk of Lethal Prostate Cancer: Prospective Analysis of a PLCO Cancer Screening Trial Cohort

Cancer Epidemiology, Biomarkers and Prevention, 2021
Background: Diet and the gut microbiome have a complex interaction that generates metabolites with an unclear effect on lethal prostate cancer risk.
Chad A. Reichard, B. Naelitz, Zeneng Wang, Xun Jia, Jianbo Li, M. Stampfer, E. Klein, S. Hazen, N. Sharifi   +8 more
semanticscholar   +1 more source

Prognostic Value of Serum Interleukin-6 Level in Hypertensive Patients with COVID-19-Associated Pneumonia

Galician Medical Journal, 2022
Background. An interleukin-6 (IL-6) is a proinflammatory cytokine which plays an important role in COVID-19-associated hyperinflammation. Aim. This study aimed to assess the predictive ability of serum IL-6 levels for the development of severe ...
Oleksii Skakun, Sergiy Fedorov, Nestor Seredyuk, Olha Verbovska   +3 more
doaj   +1 more source

Loss of function mutations in essential genes cause embryonic lethality in pigs. [PDF]

PLoS Genetics, 2019
Lethal recessive alleles cause pre- or postnatal death in homozygous affected individuals, reducing fertility. Especially in small size domestic and wild populations, those alleles might be exposed by inbreeding, caused by matings between related parents
Martijn F L Derks, Arne B Gjuvsland, Mirte Bosse, Marcos S Lopes, Maren van Son, Barbara Harlizius, Beatrice F Tan, Hanne Hamland, Eli Grindflek, Martien A M Groenen, Hendrik-Jan Megens   +10 more
doaj   +1 more source

Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice [PDF]

, 2013
International efforts to test gene function in the mouse by the systematic knockout of each gene are creating many lines in which embryonic development is compromised.
Mohun, Timothy, Richard Baldock, Andrew J. Copp, Houart, Corinne, Hurles, Matt E., Hemberger, Myriam, Wolfgang Weninger, James C. Smith, Adams, David J, Shoumo Bhattacharya, Bhattacharya, Shoumo, Corinne Houart, Hurles, Matt E, Weninger, W, Weninger, Wolfgang, Timothy Mohun, Tom Weaver, Adams, David J., Smith, James C., Baldock, Richard, Weaver, T, David J. Adams, Adams, DJ, Houart, C, Baldock, R, Mohun, T, Hemberger, M, Copp, Andrew J., Weaver, Tom, Bhattacharya, S, Smith, JC, Elizabeth Robertson, Robertson, E, Copp, Andrew J, Myriam Hemberger, Copp, AJ, Robertson, Elizabeth, Hurles, ME, Matt E. Hurles   +38 more
core   +1 more source

Biochemical responses of juvenile European sturgeon, (Huso huso) to a sub-lethal level of copper and cadmium in freshwater and brackish water environments

Journal of Environmental Health Science and Engineering, 2013
In Caspian Sea basin, sturgeons spend the larval and juvenile stages in freshwaters of rivers and then, they migrate to brackish waters of the sea where they grow and mature.
Saeed Zahedi, A. Akbarzadeh, M. Rafati, M. Banaee, Heshmat SEPEHRI MOGHADAM, Hadi Raeici   +5 more
semanticscholar   +1 more source