Results 31 to 40 of about 1,391,342 (294)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Honetaz eta hartaz [PDF]

open access: yesFontes Linguae Vasconum, 2011
Artikuluak hiru zati ditu; lehenean Wentworth Webster euskalariak jaso zituen hiru gutunen berri ematen da, hirurak beste euskalari batzuek idatziak, Luis Luciano Bonapartek, Antoine Thomson d’Abbadíe eta aita Fidel Fitak idatziak hain zuzen ere ...
Ricardo Urrizola
doaj  

« J’ay esté bien aise d’aprendre que vous soyez content du caractère de Mr Verrier »

open access: yesBulletin du Centre de Recherche du Château de Versailles, 2016
Between 1724 and 1745, Étienne Verrier, King’s Engineer, worked for the glory of France in the American colonies, constructing the Fortress of Louisbourg on the Isle Royale.
Sandrine Chabre
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

["Letters to the Lord" dance performance]

open access: yes, 2001
Video recording from The Black Academy of Arts and Letters recorded during "Praise in Dance: Letters to the Lord on his Revelation" live performance held on June 10th, 2001 at the Naomi Bruton Theatre.
St. Lukes United Methodist Church
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Dos experiencias de encierro en el ASILO del Buen Pastor de Montevideo: 1929-1934

open access: yesIdeAs, 2023
This article analyzes the experience of two young women who passed through the ASILO del Buen Pastor in Montevideo between 1929 and 1934. Their particularity was to write letters from various institutions with the aim of denouncing mistreatment ...
Facundo Álvarez Constantín
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

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