Results 41 to 50 of about 4,402,390 (304)

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

An Unpublished Autograph by Proust (and a Contemporary Pencil Portrait of Him) at the Terziere

TECA
The essay provides news and publishes the text of a short handwritten letter (unknown until today) by Marcel Proust addressed to a «chère Madame». The letter, purchased by Bononi and hung under glass on one of the walls of his library, forms a sort of ...
Gian Mario Anselmi
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

‘The Messenger to Articulate an Oral Order of Mine’: A Comparative Study of Khan Ayuka’s Oirat-Language (Clear Script) Correspondence Texts and Their Synchronic Russian Translations

Oriental Studies
Introduction. The archived Oirat-language (in Clear Script) letters by Khan Ayuka are also available in their synchronic Russian translations. The seventeenth-eighteenth communication practices could involve oral messages to be transmitted to the ...
Galina M. Yarmarkina
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Geometeric Letters [PDF]

, 1999
STRAIGHT LINE LETTERS ONLY (AEFHIKLMNTVWXYZ) Longest word made from straight line letters: possibly METHYLHEXANEAMINE (Dorland\u27s Medical Dictionary). (ZENZIZENZIZENZIc and sym-METHYLETHYLETHYLENE have straight line strings of 15, 19 letters.) Longest
Thorpe, Susan
core   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Some Remarks on Language Usage in Late Babylonian Letters

Open Linguistics, 2017
This paper deals with language usage in private and institutional letters from the Neo-Babylonian and Achaemenid periods. It analyses the usage of terms of address, greeting formulae and direct and indirect phrasing, drawing on notions of politeness ...
Schmidl Martina
doaj   +1 more source

A Content-Based Social Network Analysis of Reşat Nuri Güntekin’s Letters*

Bilgi Dünyası, 2017
Reşat Nuri Güntekin’s letters are a significant source of information regarding the establishment of the Turkish Republic among scholars. Güntekin was a key person involved in the foundation of the Turkish Republic together with other important names ...
Sümeyye Akça, Müge Akbulut
doaj   +1 more source

Briefe und Texte aus dem intellektuellen Berlin um 1800

RIDE, 2020
The digital edition “Briefe und Texte aus dem intellektuellen Berlin um 1800” collects letters and texts depicting the intellectual life of the early 19th century Berlin.
Sascha Grabsch
doaj   +1 more source