Recent Progress of Activity-Based Fluorescent Probes for Imaging Leucine Aminopeptidase [PDF]
Biosensors, 2023 Leucine aminopeptidase (LAP) is an important protease that can specifically hydrolyze Leucine residues. LAP occurs in microorganisms, plants, animals, and humans and is involved in a variety of physiological processes in the human body.
Ze-Jun Li +6 more
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Combination Vaccines of Fasciola gigantica Saposin-like Protein-2 and Leucine Aminopeptidase [PDF]
Tropical Medicine and Infectious Disease, 2023 Saposin-like protein-2 (SAP-2) and leucine aminopeptidase (LAP) are major proteins involved in the digestive process of Fasciola gigantica (Fg). Both SAP-2 and LAP are highly expressed in F.
Narin Changklungmoa +5 more
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Therapeutic effect on Alveolar echinococcosis by targeting EM-Leucine aminopeptidase [PDF]
Frontiers in Immunology, 2022 Alveolar echinococcosis (AE) is a parasitic disease caused by E. multilocularis metacestodes and it is highly prevalent in the northern hemisphere. We have previously found that vaccination with E.
Zhen Zhou +23 more
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In Silico Screening for Novel Leucine Aminopeptidase Inhibitors with 3,4-Dihydroisoquinoline Scaffold [PDF]
Molecules, 2020 Cancers are the leading cause of deaths worldwide. In 2018, an estimated 18.1 million new cancer cases and 9.6 million cancer-related deaths occurred globally.
Joanna Ziemska +2 more
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Reciprocal Expression Patterns of Placental Leucine Aminopeptidase/Insulin-Regulated Aminopeptidase and Vasopressin in the Murine Brain [PDF]
Frontiers in Molecular Biosciences, 2020 Placental leucine aminopeptidase/insulin-regulated aminopeptidase (P-LAP/IRAP) regulates vasopressin and oxytocin levels in the brain and peripheral tissues by controlled degradation of these peptides.
Yoshikuni Goto +4 more
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Phosphonic Acid Analogues of Phenylglycine as Inhibitors of Aminopeptidases: Comparison of Porcine Aminopeptidase N, Bovine Leucine Aminopeptidase, Tomato Acidic Leucine Aminopeptidase and Aminopeptidase from Barley Seeds [PDF]
Pharmaceuticals, 2019 The inhibitory activity of 14 racemic phosphonic acid analogs of phenylglycine, substituted in aromatic rings, towards porcine aminopeptidase N (pAPN) and barley seed aminopeptidase was determined experimentally.
Weronika Wanat +3 more
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MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae [PDF]
Open Biology, 2015 Aminopeptidases are part of the arsenal of virulence factors produced by bacterial pathogens that inactivate host immune peptides. Mycoplasma hyopneumoniae is a genome-reduced pathogen of swine that lacks the genetic repertoire to synthesize amino acids ...
Veronica M. Jarocki +7 more
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Characterization and structural analysis of a leucine aminopeptidase using site-directed mutagenesis [PDF]
AMB ExpressAmp0279 (EC 3.4.11.24, GenBank: CP000817.1) is a Co2+-dependent leucine aminopeptidase from the Lysinibacillus sphaericus C3-41 genome. After analyses using molecular docking and spatial structure analysis, site-directed mutagenesis mutants were ...
Yuqi Men +6 more
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Essential Role for an M17 Leucine Aminopeptidase in Encystation of Acanthamoeba castellanii. [PDF]
PLoS ONE, 2015 Encystation of Acanthamoeba leads to the formation of resilient cysts from vegetative trophozoites. This process is essential for parasite survival under unfavorable conditions such as starvation, low temperatures, and exposure to biocides.
Yu-Ran Lee +8 more
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A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei. [PDF]
PLoS Pathogens, 2017 The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle.
Priscila Peña-Diaz +4 more
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